Evidence map›Paper›PMID 39747731›Full record

ArticleGeroScience2025

The independent and combined associations of nocturnal sleep duration, sleep midpoint, and sleep onset latency with global cognitive function in older Chinese adults.

Xueyao Wu, Jiaqiang Liao, Xin Chen, Jinyu Xiao, Xinyang Dui, Tianpei Ma, Lin Hu, Xunying Zhao, Qian Bu, Mengyu Fan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xueyao WuWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiaqiang LiaoWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xin ChenWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Jinyu XiaoWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xinyang DuiWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Tianpei MaWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Lin HuWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xunying ZhaoWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Qian BuWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Mengyu FanWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Tao ZhangWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Lu LongWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xia JiangWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Ben ZhangWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. benzhang@vip.163.com.
Jiayuan LiWest China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. lijiayuan@scu.edu.cn.

Funding

Key Technologies Research and Development Program 2022YFC3600600
6 · The paper itself

Abstract

This study aims to investigate the independent and combined associations of nocturnal sleep duration, sleep midpoint, and sleep onset latency with global cognitive function in older Chinese adults. Our cross-sectional study included 4601 community-dwelling cognitively unimpaired adults aged 60 years or older from the West China Health and Aging Cohort Study. Sleep characteristics were assessed using the Pittsburgh Sleep Quality Index, and global cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Multivariable linear regression models were employed, adjusting for an extensive set of demographic, lifestyle, and comorbidity factors. Subgroup analyses were performed based on sex, age, and genetic risk profiles for cognitive performance. The mean age of participants was 69.0 ± 5.53 years, with 52.1% being female. The mean MMSE total score was 24.9 ± 3.20. Compared to the reference category for each sleep variable, sleep duration < 5 h/day or > 8 h/day, sleep midpoint earlier than 1:30 AM, and sleep latency > 60 min were each independently associated with significantly lower MMSE scores (β range - 0.36 to - 0.34; 95% confidence interval range - 0.60 to - 0.10). A combined analysis revealed that individuals with concurrent extreme sleep duration, early midpoint, and/or long latency had even lower MMSE scores, especially among those with genetically predicted poorer cognitive performance (β up to - 1.86). Multiple dimensions of sleep are independently and jointly associated with global cognitive function in older Chinese adults, highlighting the importance of a holistic approach to sleep in cognitive aging research and interventions.

Indexed as

CognitionSleepSleep LatencySleep QualityAgedChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansIndependent LivingLinear ModelsMaleMental Status and Dementia TestsMiddle AgedSleep DurationGenetic susceptibilityGlobal cognitive functionOlder peopleSleep patterns

Identifiers

PMID39747731
PMCPMC12181522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.