ArticleActa parasitologica2025
Effect of Cinnamaldehyde and Its Nanoemulsion on Acanthamoeba castellanii Cysts and Trophozoites.
Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cinnamon Essential Oil Delivery Systems: Preparation Processes, Packaging Forms, and Industrialization Potentials.Food science & nutrition · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe current study aimed to investigate the trophocidal and cysticidal activities of cinnamaldehyde (Cinn), a natural compound with known antimicrobial properties, against environmental and reference strains of Acanthamoeba castellanii. Additionally, we explored the potential benefits of Cinn formulated as a nanoemulsion (Cinn-NE) in enhancing its efficacy.
methodsCinn-NE was prepared using the ultrasonic emulsification method. The amoebicidal effect of Cinn was evaluated against both trophozoites and cysts of reference and environmental strains of Acanthamoeba, along with an assessment of whether nanotechnology enhances this effect.
resultsOur results demonstrated that Cinn exhibited strong activity against both trophozoites and cysts of Acanthamoeba. Importantly, Cinn-NE showed enhanced activity compared to pure Cinn, possibly due to increased surface area and improved interaction with microbial membranes. In this study, the difference in susceptibility to Cinn and Cinn-NE between the environmental and the reference strain of A. castellanii was observed. Acanthamoeba cysts were more resistant to the effects of Cinn or Cinn-NE than trophozoites. Additionally, we found that nutrient availability in the medium influenced the susceptibility of Acanthamoeba to Cinn and Cinn-NE. A nutrient-deficient medium reduced their vulnerability to destruction, suggesting a role for nutrient availability in the response of Acanthamoeba to antimicrobial agents.
conclusionIn conclusion, our study highlights the potential of Cinn and Cinn-NE as effective agents for combating Acanthamoeba infections. Further research is needed to elucidate the specific mechanisms underlying the differential susceptibility to Cinn, optimize its use as a treatment or surface disinfectant, and explore Acanthamoeba's cellular and molecular responses to nutrient availability.
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Registered trials
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