ArticleNature microbiology2025
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors.
Article in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Andes virus from the 2026Emerging microbes & infections · 2026Article
- Viral entry defines the hepatitis E virus species barrier in murine hepatocytes.Emerging microbes & infections · 2026Article
- Airway organoids reveal patterns of influenza A tropism and adaptation in wildlife species.Emerging microbes & infections · 2026Article
- ACE2-like Catalytic Activity in Anti-SARS-CoV-2 Spike Protein Monoclonal Antibodies.Pathogens (Basel, Switzerland) · 2026Article
- Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses.The Journal of general virology · 2026Article
- Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses.PLoS pathogens · 2026Article
- Ephrin B2 and Ephrin B3 are receptors for a novel putative henipavirus with zoonotic potential.PLoS neglected tropical diseases · 2026Article
- Identifying host-specific patterns in viral protein sequences to predict host spillover risk in animal and plant kingdoms.Scientific reports · 2026Article
- Article
- Phylogenetic Characteristics and High Prevalence of aMicroorganisms · 2025Article
- From zoonotic spillover to endemicity: the broad determinants of human coronavirus tropism.mBio · 2025Review
- Dipeptidase 1 is a functional receptor for a porcine coronavirus.Nature microbiology · 2025Article
- Rodents as potential reservoirs for toroviruses.Virology journal · 2025Article
- Newly Discovered Rustrela Virus: Current State of Knowledge About the Etiological Agent of Feline "Staggering Disease".Pathogens (Basel, Switzerland) · 2025Review
- Identification and characterization of novel bat coronaviruses in Spain.PLoS pathogens · 2025Article
- HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors.Nature communications · 2025Article
- Hidden challenges in evaluating spillover risk of zoonotic viruses using machine learning models.Communications medicine · 2025Article
- Viral entry as a low barrier to zoonosis.Nature microbiology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cross-species transmission of animal viruses poses a threat to human health. However, systematic experimental assessments of these risks remain scarce. A critical step in viral infection is cellular internalization mediated by viral receptor-binding proteins (RBPs). Here we constructed viral pseudotypes bearing the RBPs of 102 enveloped RNA viruses and assayed their infectivity across 5,202 RBP-cell combinations. This showed that most of the tested viruses have the potential to enter human cells. Pseudotype infectivity varied widely among the 14 viral families examined and was influenced by RBP characteristics, host of origin and target cell type. Cellular gene expression data revealed that the availability of specific cell-surface receptors is not necessarily the main factor limiting viral entry and that additional host factors must be considered. Altogether, these results suggest weak interspecies barriers in the early stages of infection and advance our understanding of the molecular interactions driving viral zoonosis.
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