ReviewNature protocols2025
Standardized workflow for multiplexed charge detection mass spectrometry on orbitrap analyzers.
Abstract readReview
In one paragraph
Review in Nature protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Analyses of Individual Singly Charged Ions Using a High-Field Orbitrap Analyzer.Analytical chemistry · 2026Article
- Probing Proteoform Heterogeneity From Single Human Oocytes.Molecular & cellular proteomics : MCP · 2026Article
- Proteoform profiling of endogenous single cells from rat hippocampus at scale.Nature biotechnology · 2026Article
- Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85-110 kDa) Regulated by Actomyosin Contractility.Angewandte Chemie (International ed. in English) · 2025Article
- Effects of Hydration on Transthyretin Conformational Dynamics and Oligomerization.Biochemistry · 2025Article
- Next-generation protein sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6.Analytical and bioanalytical chemistry · 2025Article
- An Online Buffer Exchange Platform for Charge Detection Mass Spectrometry Analysis of AAVs and AAV-Antibody Complexes.Journal of the American Society for Mass Spectrometry · 2025Article
- Wavelength Dependence of Intact Protein Extraction Using Femtosecond Laser Ablation.The journal of physical chemistry letters · 2025Article
- A Fast Neural Network for Isotopic Charge State Assignment.Journal of the American Chemical Society · 2025Article
- Electron Capture-Induced Charge Reduction Benefits the Recording of Ultralong Transients in Orbitrap-Based Individual-Ion Mass Spectrometry.Analytical chemistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Pei SuDepartments of Molecular Biosciences, Chemistry and Chemical and Biological Engineering and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-6148-0181
John P McGeeDepartments of Molecular Biosciences, Chemistry and Chemical and Biological Engineering and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-0527-8904
Michael A R HollasProteomics Center of Excellence, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Ryan T FellersProteomics Center of Excellence, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Kenneth R DurbinProteomics Center of Excellence, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Joseph B GreerProteomics Center of Excellence, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Bryan P EarlyProteomics Center of Excellence, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Ping F YipThermo Fisher Scientific, San Jose, CA, USA.
Vlad ZabrouskovThermo Fisher Scientific, San Jose, CA, USA.
Kristina SrzentićThermo Fisher Scientific, San Jose, CA, USA.
Michael W SenkoThermo Fisher Scientific, San Jose, CA, USA.
Philip D ComptonProteomics Center of Excellence, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Neil L KelleherDepartments of Molecular Biosciences, Chemistry and Chemical and Biological Engineering and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA. n-kelleher@northwestern.edu.ORCID 0000-0002-8815-3372
Jared O KafaderDepartments of Molecular Biosciences, Chemistry and Chemical and Biological Engineering and the Feinberg School of Medicine, Northwestern University, Evanston, IL, USA. jared.kafader@northwestern.edu.
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9MThe UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Jonathan V. Sweedler · 2004 to 2026
$24.9MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MSingle Cell Proteoform Profiling using Top-Down Mass SpectrometryK99AI183290 · NIAID · NORTHWESTERN UNIVERSITY · PI SU, PEI · 2024 to 2025
$249kAlzheimer's Disease Characterization via a Novel Native Mass Spectrometry PlatformF31AG069456 · NIA · NORTHWESTERN UNIVERSITY · PI MCGEE, JOHN PHILIP · 2020 to 2021
$84kNCI NIH HHS P30 CA060553NIAID NIH HHS K99 AI183290NIA NIH HHS F31 AG069456NIDA NIH HHS P30 DA018310NIGMS NIH HHS P41 GM108569U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA060553U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) K99AI183290U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P41GM108569U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) F31AG069456U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) P30DA018310
Abstract
Individual ion mass spectrometry (I
Indexed as
Mass SpectrometryHumansProteinsWorkflowProteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.