ArticleScientific reports2025
Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Investigating the diagnostic accuracy of physical examination in digital nerve injury: a study within a trial.The Journal of hand surgery, European volume · 2026Trial
- An Ultrasonographic Study of the Superficial Radial Nerve in Healthy Subjects: Suggesting a Safe Zone for Wrist Extensor Compartment Injections.Diagnostics (Basel, Switzerland) · 2026Article
- Quantitative Assessment of Peripheral Nerve Echogenicity in Children and Adolescents Aged 2-17 Years: A Retrospective Cross-Sectional Ultrasound Study.Journal of clinical medicine · 2026Article
- The Correlation Between Smartphone Use and Compressive Ulnar Neuropathy at the Elbow: A Retrospective Study.Journal of clinical medicine · 2026Article
- Nerve Ultrasound for the Diagnosis of Tarsal Tunnel Syndrome: Findings in 26 Clinically and Electrophysiologically Confirmed Feet.Journal of clinical medicine · 2026Article
- Deep Learning-Based Segmentation of the Ulnar Nerve in Ultrasound Images.Medicina (Kaunas, Lithuania) · 2026Article
- Phase-Specific Evaluation of Sciatic Nerve Regeneration in Preclinical Studies: A Review of Functional Assessment, Emerging Therapies, and Translational Value.International journal of molecular sciences · 2025Review
- Preserved fascicular architecture predicts neuroma pain: a morphometric study.Acta neuropathologica communications · 2025Article
- 3D Microstructural Characterization of Human Deep Fascia Using Optical Projection Tomography, Digital Light Sheet Microscopy, and Magnetic Resonance Microscopy.Microscopy research and technique · 2025Article
- Brachial Plexopathies: A Comprehensive Radiologic Method Integrating Ultrasound and MRI.Journal of clinical medicine · 2025Review
- Peripheral Nerve Decellularisation Protocol for Allogeneic Transplantation: From Tissue Procurement to Banking.International journal of molecular sciences · 2025Article
- Comparison of Ultrasound Versus Ultrasound with Nerve Stimulator-Guided Infraclavicular Block Anesthesia Methods in Pediatric Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Ultrasonography of the Vagus Nerve for ALS Patients: Correlations with Clinical Data and Dysfunction of the Autonomic Nervous System.Medicina (Kaunas, Lithuania) · 2025Article
- Synergistic Effect of Polydeoxyribonucleotides with Low-Level Lasers on the Regeneration of Crush-Injured Facial Nerves.Journal of clinical medicine · 2025Article
- Correlation Between the Clinical and Histopathological Results in Experimental Sciatic Nerve Defect Surgery.Medicina (Kaunas, Lithuania) · 2025Article
- Imaging Retrospective Study Regarding the Variability of the Osseous Landmarks for IAN Block.Journal of clinical medicine · 2025Article
- Prognostic value of multimodal neurophysiological - ultrasound assessments in median and ulnar nerve injury repair.American journal of translational research · 2025Article
- High-Field Diffusion Tensor Imaging of Median, Tibial, and Sural Nerves in Type 2 Diabetes With Morphometric Analysis.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
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Authors and funding
8 authors.
Funding
Abstract
This study aimed to compare the fascicular anatomy of upper limb nerves visualized using in situ high-resolution ultrasound (HRUS) with ex vivo imaging modalities, namely, magnetic resonance microscopy (MRM), histological cross-sections (HCS), and optical projection tomography (OPT). The median, ulnar, and superficial branch of radial nerve (n = 41) were visualized in 14 cadaveric upper limbs using 22-MHz HRUS. Subsequently, the nerves were excised, imaged with different microscopic techniques, and their morphometric properties were compared. HRUS accurately differentiated 51-74% of fascicles, while MRM detected 87-92% of fascicles when compared to the referential HCS. Among the compared modalities, HRUS demonstrated the smallest fascicular ratios and fascicular cross-sectional areas, but the largest nerve cross-sectional areas. The probability of a fascicle depicted on HRUS representing a cluster of multiple fascicles on the referential HCS increased with the fascicular size, with some differences observed between the larger median and ulnar nerves and the smaller radial nerves. Accordingly, HRUS fascicle differentiation necessitates cautious interpretation, as larger fascicles are more likely to represent clusters. Although HCS is considered the reference modality, alterations in nerve cross-sectional areas or roundness during sample processing should be acknowledged.
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