ArticleNature plants2025
Lysozyme-coated nanoparticles for active uptake and delivery of synthetic RNA and plasmid-encoded genes in plants.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Behind (cell) walls.Nature biotechnology · 2026Article
- The unfulfilled potential of nanocarriers for RNA delivery in antiviral crop protection.Nature plants · 2026Review
- Bioactive Amino-Carbon Dots for Sustainable Crop Protection: Cellular Uptake and Metabolomic Insights into the Antifungal and Antibacterial Activity in Tomato Plants.ACS applied materials & interfaces · 2026Article
- Genetic Transformation of Catharanthus roseus with Simplified Nanocarrier-Based Gene Delivery Method Using Green Synthesized Superparamagnetic Iron Oxide Nanoparticles.Molecular biotechnology · 2026Article
- High-Efficiency and Eco-Friendly Management of Multiple Fungal Diseases by a Novel Carbon Dots sCDP Delivered RNA Nano-Pesticides.Plant biotechnology journal · 2026Article
- Biotechnological and genetic innovations to enhance sorghum adaptation under climate change.Frontiers in plant science · 2026Review
- Genome assembly and DNA methylation variation in an epimutant population of hybrid poplar clone NL895.Plant physiology · 2025Article
- Smart nanocarriers for plant genetic engineering.Plant communications · 2025Article
- Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems.Journal of nanobiotechnology · 2025Review
- Carboxymethyl Cellulose Surface Modification Alleviates the Toxicity of Fe-MOFs to Rice and Improves Iron Absorption.Nanomaterials (Basel, Switzerland) · 2025Article
- Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon.Communications biology · 2025Article
- Lysozyme-coated LDHs boost trait control.Nature plants · 2025Article
- A Brief History of Canola Genetic Gains: From Classical Breeding to Genome Editing.Physiologia plantarumReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Nanoparticle-mediated delivery of nucleic acids and proteins into intact plants has the potential to modify metabolic pathways and confer desirable traits in crops. Here we show that layered double hydroxide (LDH) nanosheets coated with lysozyme are actively taken up into the root tip, root hairs and lateral root junctions by endocytosis, and translocate via an active membrane trafficking pathway in plants. Lysozyme coating enhanced nanosheet uptake by (1) loosening the plant cell wall and (2) stimulating the expression of endocytosis and other membrane trafficking genes. The lysozyme-coated nanosheets efficiently delivered synthetic mRNA, double-stranded RNA, small interfering RNA and plasmid DNA up to 15 kb in size into tobacco roots, and also functional nucleic acids into leaves, callus, flowers and developing pollen of dicot and monocot species. Thus, lysozyme-coated LDH nanoparticles are a versatile tool for efficiently delivering functional nucleic acids into plants.
Indexed as
Identifiers
39747606What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.