ArticleNature genetics2025
Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Reactivation of a loss-of-function SlGLK2 allele by frame-restoring genome editing in tomato.Plant cell reports · 2026Article
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Molecular Targets and Trait Innovation in CRISPR-Edited Vegetable Crops: An Up-to-Date Review (2020-2026).Plants (Basel, Switzerland) · 2026Review
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Prioritization of deleterious mutations informs genomic prediction and increases the rate of gain in common bean (Phaseolus vulgaris L.), a simulation study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- Boosting cytosine base editing in potato through synergistic optimization.Horticulture research · 2026Article
- Remodeling of the tuberization-controlling FLOWERING LOCUS T genes from non-tuberizing ancestor to potato.The Plant journal : for cell and molecular biology · 2026Article
- Many roads lead to a plant cistrome: mapping and interpreting transcription factor binding in plants.Genome biology · 2026Review
- Creating inbred lines for heterosis utilization in alfalfa.Science China. Life sciences · 2026Article
- Application of a GRF-GIF chimera enhances plant regeneration for genome editing in tomato.Plant biotechnology journal · 2025Article
- Optimizing plant size for vertical farming by editing stem length regulators.Plant biotechnology journal · 2025Article
- Synergistic optimization enhancing the precision and efficiency of cytosine base editors in poplar.Communications biology · 2025Article
- Elevated Mutation Burdens in Canadian Oat and Wheat Cultivars Released over the Past Century.Cells · 2025Article
- Dancing molecules: group A bZIPs and PEBPs at the heart of plant development and stress responses.Journal of experimental botany · 2025Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Crop genomes accumulate deleterious mutations-a phenomenon known as the cost of domestication. Precision genome editing has been proposed to eliminate such potentially harmful mutations; however, experimental demonstration is lacking. Here we identified a deleterious mutation in the tomato transcription factor SUPPRESSOR OF SP2 (SSP2), which became prevalent in the domesticated germplasm and diminished DNA binding to genome-wide targets. We found that the action of SSP2 is partially redundant with that of its paralog SSP in regulating shoot and inflorescence architecture. However, redundancy was compromised during tomato domestication and lost completely in the closely related species Physalis grisea, in which a single ortholog regulates shoot branching. We applied base editing to directly repair the deleterious mutation in cultivated tomato and obtained plants with compact growth that provide an early fruit yield. Our work shows how deleterious variants have sensitized modern genotypes for phenotypic tuning and illustrates how repairing deleterious mutations with genome editing may allow predictable crop improvement.
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