ArticleScientific reports2025
Association of triglyceride glucose-related obesity indices with sarcopenia among U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of the triglyceride-glucose index with the risk of sarcopenia: a meta-analysis with clinical implications.BMC endocrine disorders · 2026Pooled it
- Associations between the triglyceride‒glucose index and the odds of low muscle mass and sarcopenia: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Pooled it
- Triglyceride-related metabolic indices and low relative muscle mass: a cross-sectional analysis of SMILE and NHANES.Endocrine · 2026Article
- Modified cardiometabolic index outperforms conventional indices in discriminating relative muscle loss: a cross-sectional analysis of NHANES 2011-2018.European journal of medical research · 2026Article
- Association of triglyceride-glucose muscle loss index with major adverse cardiovascular events in angina patients: the potential mediating role of inflammation.Frontiers in medicine · 2026Article
- Risk prediction of sarcopenia in a large health checkup population: development and validation of a dynamic online nomogram.Frontiers in public health · 2026Article
- Association between triglyceride-glucose muscle-loss index (TyG-MLI) and incident cardiovascular disease: a prospective cohort study in the UK biobank.Cardiovascular diabetology · 2025Article
- Organokine-Mediated Crosstalk: A Systems Biology Perspective on the Pathogenesis of MASLD-A Narrative Review.International journal of molecular sciences · 2025Review
- Association between triglyceride glucose-body mass index and preeclampsia risk in advanced maternal age pregnant women-a retrospective cohort study.Scientific reports · 2025Article
- Fatty Liver Index vs. Biochemical-Anthropometric Indices: Diagnosing Metabolic Dysfunction-Associated Steatotic Liver Disease with Non-Invasive Tools.Diagnostics (Basel, Switzerland) · 2025Article
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Abstract
The triglyceride glucose (TyG) index-related obesity indices have been proposed as reliable indicators of insulin resistance. This study aims to investigate the association between TyG index-related obesity indices and sarcopenia as well as their potential as a tool for screening sarcopenic patients. A cross-sectional study was conducted involving 7,161 participants aged 18 and above from the National Health and Nutrition Examination Survey. TyG index and TyG index-related obesity indices, including triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-waist-to-height ratio (TyG-WHtR) were determined using standard formulas. The ratio of appendicular skeletal muscle mass to BMI were used to assess sarcopenia. The relationship between the TyG index as well as TyG index-related obesity indices and sarcopenia was investigated using restricted cubic spline analysis and multivariate logistic regression analysis. The diagnostic value of the TyG index and TyG index -related obesity indices for sarcopenia was compared using the receiver operating characteristic (ROC) curve. In the fully adjusted regression model, a positive correlation was observed between the TyG-WHtR index and sarcopenia (for each one-unit increase in TyG-WHtR index: OR = 3.57, 95% CI: 2.71-4.71, P < 0.001). Additionally, regression analyses demonstrated TyG-WHtR as a significant predictor of sarcopenia with the highest odds ratio, reaching 12.50 (95% CI: 6.13-25.70, P < 0.001) for the upper fourth quartile (Q4) compared to the first quartile, followed by followed by TyG-BMI (Q4: 3.34; 95% CI: 1.92-5.80, P < 0.001) and TyG-WC (Q4: 1.95; 95% CI: 1.04-3.68, P < 0.001). The RCS curve fitting analysis indicated a U-shaped relationship between TyG-WHtR and the diagnosis of sarcopenia, with an inflection point at 4.02. Furthermore, in the ROC analysis, the AUC for the diagnosis of sarcopenia was largest for TyG-WHtR (0.79, P < 0.001). The TyG ndex-related obesity indices, especially TyG-WHtR, have been shown to be more effective in identifying sarcopenia patients than TyG alone.
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