Evidence map›Paper›PMID 39747228›Full record

ArticleScientific reports2025

Ironing out differences in attenuation and blooming artifact in acute stroke thrombi.

Aglae Velasco Gonzalez, Dennis Görlich, Boris Buerke, Cristina Sauerland, Norbert Meier, Manfred Fobker, Ray McCarthy, Astrid Jeibmann, Walter Heindel, Andreas Faldum and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aglae Velasco GonzalezClinic for Radiology, Neuroradiology, University of Münster and University Hospital Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany. velascoa@uni-muenster.de.ORCID 0000-0001-6865-6864
Dennis GörlichInstitute of Biostatistics and Clinical Research, University of Münster, 48149, Münster, Schmeddingstraße 56, Germany.
Boris BuerkeClinic for Radiology, Neuroradiology, University of Münster and University Hospital Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany.
Cristina SauerlandInstitute of Biostatistics and Clinical Research, University of Münster, 48149, Münster, Schmeddingstraße 56, Germany.
Norbert MeierMedical Physics, Clinic for Radiology, University of Münster and University Hospital of Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany.
Manfred FobkerCenter for Laboratory Medicine, University Hospital Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany.
Ray McCarthyCerenovus, Galway Neuro Technology Centre, Galway, Mervue Business Park, Ireland.
Astrid JeibmannInstitute of Neuropathology, University Hospital Münster, 48149, Münster, Pottkamp 2, Germany.
Walter HeindelClinic for Radiology, Neuroradiology, University of Münster and University Hospital Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany.
Andreas FaldumInstitute of Biostatistics and Clinical Research, University of Münster, 48149, Münster, Schmeddingstraße 56, Germany.
Harald KugelMedical Physics, Clinic for Radiology, University of Münster and University Hospital of Münster, 48149, Münster, Albert-Schweitzer-Campus 1, Building A1, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to improve our understanding of acute ischemic stroke clot imaging by integrating CT attenuation information with MRI susceptibility signal of thrombi. For this proof-of-principle experimental study, fifty-seven clot analogs were produced using ovine venous blood with a broad histological spectrum. Each clot analog was analyzed to determine its RBC content and chemical composition, including water, Fe III, sodium, pH, and pO2. Non-contrast CT and a susceptibility-weighted MRI sequence were used for imaging. The study found that RBC content correlated more accurately than iron content with clot attenuation on CT. There was a strong correlation between Fe III content and RBC percentage in clots. Specifically, changes in RBC content accounted for 64% of the variance in Fe III content (R2 = 0.640; p < .0001). Thrombi with blooming artifacts (BA) displayed higher attenuation on non-contrast CT than those without (73.4 vs. 40 HU, p < .0001) and had the highest RBC and iron contents. The cut-off value of 1242 µg/g of iron predicted blooming artifacts with high sensitivity and specificity. The pH level strongly affected the appearance of blooming artifacts, particularly for negative clots with high RBC content. These findings provide significant insights into the imaging behavior of acute ischemic stroke clots across both imaging modalities and could potentially improve the diagnosis and treatment of acute stroke patients. Furthermore, these results open the possibility for future research aimed at developing pH-modulated therapeutic strategies based on the acid-base state of thrombi.

Indexed as

ArtifactsErythrocytesMagnetic Resonance ImagingStrokeThrombosisAnimalsHumansHydrogen-Ion ConcentrationIronIschemic StrokeSheepTomography, X-Ray ComputedIronBlood clotDecision treesHelical CTIronRed blood cells

Identifiers

PMID39747228
PMCPMC11697157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.