Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Natalie L JohnsonDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of Medicine, Gainesville, FL, USA.
Anamaria Cotelo-LarreaDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of Medicine, Gainesville, FL, USA.
Lucas A StetzikDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of Medicine, Gainesville, FL, USA.
Umit M AkkayaDepartment of Computer Engineering, Gebze Technical University, Kocaeli, Turkey.ORCID 0000-0002-5247-4860
Zihao ZhangDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of Medicine, Gainesville, FL, USA.
Marie A GadziolaDepartment of Psychology, University of Toronto Scarborough, Toronto, ON, Canada.
Adrienn G VargaDepartment of Neuroscience, Breathing Research and Therapeutics Center, McKnight Brain Institute; University of Florida College of Medicine, Gainesville, FL, USA.
Minghong MaDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5027-9623
Daniel W WessonDepartment of Pharmacology and Therapeutics, Florida Chemical Senses Institute, Center for Addiction Research and Education; University of Florida College of Medicine, Gainesville, FL, USA. danielwesson@ufl.edu.ORCID 0000-0002-3192-3866
Funding
Olfactory Modulation of Respiration-Entrained Brain Activity and BehaviorR01DC006213 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI MA, MINGHONG · 2005 to 2024
$8.2M
Striatal mechanisms for e-cigarette reinforcement by flavorantsR01DA049545 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DE BIASI, MARIELLA, MA, MINGHONG · 2019 to 2023
$3.2M
Linking Synucleinopathy and Dysfunction of Olfactory PathwaysR01DC016519 · NIDCD · VAN ANDEL RESEARCH INSTITUTE · PI MOORE, DARREN JOHN, WESSON, DANIEL W · 2017 to 2021
$2.8M
Novel Role of a Ventral Striatal Circuit in Motor ControlR01NS117061 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI FUCCILLO, MARC V, MA, MINGHONG · 2021 to 2025
$2.4M
INTER-REGIONAL CODING OF ODOR VALENCE BY NEURAL ENSEMBLESR01DC014443 · NIDCD · UNIVERSITY OF FLORIDA · PI WESSON, DANIEL W · 2015 to 2019
$2.3M
Circuitry and function of ventral striatum subregionsR01DA049449 · NIDA · UNIVERSITY OF FLORIDA · PI MA, MINGHONG, WESSON, DANIEL W · 2020 to 2024
$2.1M
Training Program in Chemosensory ScienceT32DC015994 · NIDCD · UNIVERSITY OF FLORIDA · PI Daniel W Wesson · 2018 to 2026
$1.4M
Role of an arousal circuit in respiration and opioid-induced respiratory depressionR00HL159232 · NHLBI · UNIVERSITY OF FLORIDA · PI VARGA, ADRIENN GABRIELLA · 2023 to 2025
$747k
Harnessing biological rhythms for a resilient social motif generatorR34DA059718 · NIDA · UNIVERSITY OF FLORIDA · PI PADILLA COREANO, NANCY, SAXENA, SHREYA · 2024 to 2025
$676k
Olfactory Mechanisms Supporting Attraction to e-Cigarette OdorsF31DC020364 · NIDCD · UNIVERSITY OF FLORIDA · PI JOHNSON, NATALIE LEWIS · 2022 to 2023
$90k
NHLBI NIH HHS R00 HL159232NIDA NIH HHS R01 DA049449NIDA NIH HHS R01 DA049545NIDA NIH HHS R34 DA059718NIDCD NIH HHS F31 DC020364NIDCD NIH HHS R01 DC006213NIDCD NIH HHS R01 DC014443NIDCD NIH HHS R01 DC016519NIDCD NIH HHS T32 DC015994NINDS NIH HHS R01 NS117061U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL159232U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS117061U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) F31DC020364U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC006213U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC014443U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01DC016519U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) T32015994U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA049449U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA049545U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R34DA059718
6 · The paper itself
Abstract
Sniffing is a motivated behavior displayed by nearly all terrestrial vertebrates. While sniffing is associated with acquiring and processing odors, sniffing is also intertwined with affective and motivated states. The systems which influence the display of sniffing are unclear. Here, we report that dopamine release into the ventral striatum in mice is coupled with bouts of sniffing and that stimulation of dopaminergic terminals in these regions drives increases in respiratory rate to initiate sniffing whereas inhibition of these terminals reduces respiratory rate. Both the firing of individual neurons and the activity of post-synaptic D1 and D2 dopamine receptor-expressing neurons are coupled with sniffing and local antagonism of D1 and D2 receptors squelches sniffing. Together, these results support a model whereby sniffing can be initiated by dopamine's actions upon ventral striatum neurons. The nature of sniffing being integral to both olfaction and motivated behaviors implicates this circuit in a wide array of functions.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior. · full record | OpenQuestion