ArticleNature communications2025
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Na
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
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Who cites it
11 citing papers in PubMed.
- mTORC2-NaChannels (Austin, Tex.) · 2026Article
- Article
- Beyond Ion Channels: Emerging Roles of FGF12 in Cellular Regulation and Cancer Progression.Cells · 2026Review
- Article
- Uncovering molecular determinants of potency and binding affinity in hit compounds targeting FGF14/Nav1.6 complex.Journal of cheminformatics · 2025Article
- Cannabidiol Reduces D1 and D2 Medium Spiny Neuron Excitability in the Nucleus Accumbens Core.bioRxiv : the preprint server for biology · 2025Article
- Contusive spinal cord injury causes Nav1.8 dysfunction to upregulate small sensory neuron excitability.The Journal of physiology · 2025Article
- FGF14 Peptide Derivative Differentially Regulates Nav1.2 and NaLife (Basel, Switzerland) · 2025Article
- Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.The Journal of clinical investigation · 2025Article
- Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Deletion of Fgf14 confers resilience to basal and stress-induced depressive-like behavior and reduces anxiety in mice.Translational psychiatry · 2025Article
Corrections and comments
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Authors and funding
38 authors.
Nolan M Dvorak *Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0003-1280-9918
Paul A Wadsworth *Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Guillermo Aquino-Miranda *Department of Neurobiology and Anatomy, University of Texas Health Science Center, Houston, TX, USA.
Pingyuan WangDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Douglas S EngelkeDepartment of Neurobiology and Anatomy, University of Texas Health Science Center, Houston, TX, USA.
Jingheng ZhouNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.ORCID 0000-0003-0280-6166
Nghi NguyenHigh-Throughput Research and Screening Center, Texas A&M Health Science Center, Houston, TX, USA.
Aditya K SinghDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0001-7549-8163
Giuseppe AcetoDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-7530-6835
Zahra HaghighijooDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Isabella I SmithDepartment of Neurobiology and Anatomy, University of Texas Health Science Center, Houston, TX, USA.
Nana GoodeDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0009-0005-1254-3832
Mingxiang ZhouDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Yosef AvchalumovDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Evan P TroendleDepartment of Chemistry, King's College London 7 Trinity Street, London, UK.ORCID 0000-0003-4825-4088
Cynthia M TapiaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Haiying ChenDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Reid T PowellHigh-Throughput Research and Screening Center, Texas A&M Health Science Center, Houston, TX, USA.ORCID 0000-0002-6242-8315
Timothy J BaumgartnerDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Jully SinghDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Leandra KoffDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Jessica Di ReDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Ann E WadsworthDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Mate MarosiDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Marc R AzarBehavioral Pharma Inc., 505 Coast Blvd. South, Suite 212, La Jolla, CA, USA.
Kristina EliasBehavioral Pharma Inc., 505 Coast Blvd. South, Suite 212, La Jolla, CA, USA.
Paul LehmannDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Yorkiris M Mármol ContrerasDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Poonam ShahDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Hector GutierrezDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-7474-4876
Thomas A GreenDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Martin B UlmschneiderDepartment of Chemistry, King's College London 7 Trinity Street, London, UK.ORCID 0000-0001-8103-0516
Marcello D'AscenzoDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0003-0073-412X
Clifford StephanHigh-Throughput Research and Screening Center, Texas A&M Health Science Center, Houston, TX, USA.ORCID 0000-0003-0657-6484
Guohong CuiNeurobiology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.ORCID 0000-0002-4555-028X
Fabricio H Do MonteDepartment of Neurobiology and Anatomy, University of Texas Health Science Center, Houston, TX, USA.ORCID 0000-0002-1079-0064
Jia ZhouDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0002-2811-1090
Fernanda LaezzaDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA. felaezza@utmb.edu.ORCID 0000-0003-1141-1852
Funding
HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0MMolecular Mechanisms of Environmental InjuryT32ES007254 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI AMEREDES, BILL T · 1990 to 2022
$6.6MProbing brain circuit and behavior with protein:protein interaction modulatorsR01MH132226 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Fernanda Laezza, Jia Zhou · 2023 to 2026
$3.2MNeurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0MNeural Circuits Balancing Reward-Approaching with Threat-AvoidanceR01MH120136 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DO MONTE, FABRICIO HOFFMANN · 2020 to 2024
$2.8MCorticothalamic circuits mediating behavioral adaptations to unexpected reward omissionR01MH131570 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BEIERLEIN, MICHAEL, DO MONTE, FABRICIO HOFFMANN · 2023 to 2025
$1.8MDiscovery of Chemical Probes for Psychiatric Disorders and AddictionR01MH111107 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, ZHOU, JIA · 2016 to 2018
$1.6MHigh-Throughput Automated Patch Clamp SystemS10OD032293 · OD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SPUDICH, JOHN LEE · 2022 to 2022
$599kClinical and Behavioral Science Training in Aging and Health DisparitiesT32AG051131 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARKIDES, KYRIAKOS S · 2015 to 2019
$436kFGF13: a novel druggable target for treating substance abuse disordersU18DA052504 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2020
$237kThalamic circuits in the integration of fear and rewardK99MH105549 · NIMH · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI DO MONTE, FABRICIO HOFFMANN · 2015 to 2016
$137kNIA NIH HHS T32 AG051131NIDA NIH HHS U18 DA052504NIEHS NIH HHS T32 ES007254NIGMS NIH HHS T32 GM008280NIH HHS S10 OD032293NIMH NIH HHS K99 MH105549NIMH NIH HHS R01 MH111107NIMH NIH HHS R01 MH120136NIMH NIH HHS R01 MH124351NIMH NIH HHS R01 MH131570NIMH NIH HHS R01 MH132226University of Texas Medical Branch (University of Texas Medical Branch at Galveston) Edith Robert Zinn Chair Endowment in Drug DiscoveryUniversity of Texas Medical Branch (University of Texas Medical Branch at Galveston) John D. Stobo, M.D. Distinguished Chair Endowment
Abstract
Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 (FGF14)/voltage-gated Na
Indexed as
Fibroblast Growth FactorsNAV1.6 Voltage-Gated Sodium ChannelNeuronsNucleus AccumbensAnimalsBehavior, AnimalHEK293 CellsHumansMaleMiceMice, Inbred C57BLMotivationfibroblast growth factor 14Fibroblast Growth FactorsNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.