Evidence map›Paper›PMID 39747136›Full record

ArticleScientific reports2025

New formyl indole derivatives based on thiobarbituric acid and their nano-formulations; synthesis, characterization, parasitology and histopathology investigations.

Walaa Ali Abdelhalim, Ahmed R Rabee, Saied M Soliman, Mohamed Hagar, Esraa A Moneer, Basant A Bakr, Assem Barakat, Matti Haukka, Hanaa A Rasheed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Walaa Ali AbdelhalimChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt.
Ahmed R RabeeChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. ahmedrabee@alexu.edu.eg.
Saied M SolimanChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. Saeed.soliman@alexu.edu.eg.
Mohamed HagarChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt. mohamed.hagar@alexu.edu.eg.
Esraa A MoneerDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21500, Egypt.
Basant A BakrDepartment of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.
Assem BarakatDepartment of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
Matti HaukkaDepartment of Chemistry, University of Jyväskylä, P.O. Box 35, Jyväskylä, FI-40014, Finland.
Hanaa A RasheedChemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt.

Funding

the Researchers Supporting Project (RSP2024R64), King Saud University, Riyadh, Saudi Arabia RSP2024R64
6 · The paper itself

Abstract

New formyl indole derivatives based on thiobarbituric acid were designed for targeting parasitological applications. The new compounds (5-((1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (3a), and 5-((1-benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (3b) were synthesized as thioxodihydropyrimidine derivatives via aldol condensation reaction. The structures of the synthesized compounds were confirmed based on their spectral data via FT-IR,

Indexed as

IndolesThiobarbituratesAnimalsMiceNanoparticlesIndolesThiobarbituratesthiobarbituric acidAldol condensationHistopathology investigationNano formulationParasitologyThiobarbituric acid

Identifiers

PMID39747136
PMCPMC11696224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.