ArticleNPJ science of food2025
Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Fabric-Templated Co-Deposition of Nanofiber-Reinforced Composite Films with Ordered Surface Arrays for Ultrasensitive Wearable Sensing.Polymers · 2026Article
- Effect of a Polysaccharide from CultivatedNutrients · 2026Article
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.Nutrients · 2026Review
- [A study on effect of a novel total nutritional composition for repairing full-thickness skin defects in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Screening and characterization of a novel cupin-like polypeptide from Oyster (Food chemistry: X · 2026Article
- Intervention of Fish (Foods (Basel, Switzerland) · 2026Article
- Microfluidic-based oral mucoadhesive nanozyme microspheres for immune modulation of xerostomia.Materials today. Bio · 2026Article
- Immune-Modulatory Effects of Bioactive Collagen Peptides Improve Skin Health in Middle-Aged Women.Dermatology and therapy · 2026Article
- Biomaterial-associated molecular patterns (BAMPs) modulate macrophage polarization in bone grafting.PloS one · 2026Article
- Influence of Oral Collagen Peptides on Skin Biophysical Properties in Humans: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2026Review
- Development of a 3D-printable bioactive polycaprolactone-collagen peptides filament for biomedical applications.Scientific reports · 2025Article
- Article
- Trimethyl Chitosan-Engineered Cod Skin Peptide Nanosystems Alleviate Behavioral and Cognitive Deficits in D-Galactose-Induced Alzheimer's Disease Model Mice.Marine drugs · 2025Article
- Functional Benefits of Low-Molecular-Weight Collagen Peptide in Achilles Tendon and Medial Collateral Ligament Injuries and Anterior Cruciate Ligament Transection-Induced Osteoarthritis.Journal of microbiology and biotechnology · 2025Article
- Recent advances in the therapeutics and modes of action of a range of agents used to treat ulcerative colitis and related inflammatory conditions.Inflammopharmacology · 2025Review
- Enzymatic valorization of fishery by-products: harnessing cold-adapted marine proteases for sustainable production of bioactive peptides.Archives of microbiology · 2025Review
- Article
- In Silico Screening and Identification of Functional Peptides from Yak Bone Collagen Hydrolysates: Antioxidant and Osteoblastic Activities.International journal of molecular sciences · 2025Article
- Bone-protective effects of deer-hide gelatin in cyclophosphamide-induced osteoporosis rats.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects by inhibiting the secretion of pro-inflammatory cytokines and reducing oxidative stress in vitro. In vivo, collagen peptides significantly reduced colonic tissue damage, modulated serum cytokine balance, increased the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue, enhanced the abundance of beneficial bacteria while reducing harmful bacteria, and restored microbial balance. In addition, collagen peptides ameliorated colitis in vivo by inhibiting the phosphorylation of NF-κB p65, IκBα and p38 MAPK in the NF-κB/MAPK signaling pathway. Based on these findings, collagen peptides could serve as potential therapeutic agents for managing ulcerative colitis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.