Evidence map›Paper›PMID 39747033›Full record

ArticleNature communications2025

E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development.

Michela Di Michele, Aurore Attina, Pierre-François Roux, Imène Tabet, Sophie Laguesse, Javier Florido, Morane Houdeville, Armelle Choquet, Betty Encislai, Giuseppe Arena and 35 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Michela Di MicheleInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France. michela.di-michele@enscm.fr.ORCID 0000-0002-0739-5004
Aurore Attina *IRMB-PPC, Univ. Montpellier, INSERM, CHU Montpellier, CNRS, Montpellier, France.
Pierre-François Roux *Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.ORCID 0000-0002-0695-4206
Imène TabetInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Sophie LaguesseLaboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, CHU Sart Tilman, 4000, Liège, Belgium.
Javier FloridoInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.ORCID 0000-0001-7541-4898
Morane HoudevilleInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Armelle ChoquetInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Betty EncislaiInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Giuseppe ArenaLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.ORCID 0000-0003-2398-5503
Carlo De BlasioInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.ORCID 0000-0003-2388-2555
Olivia WendlingUniversité de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), Illkirch, France.
François-Xavier FrenoisDepartment of Pathology, CHU, Imag'IN Platform, IUCT-Oncopole, Toulouse, France.
Laura PaponInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Lucille StuaniInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.ORCID 0000-0001-6116-981X
Maryse FuentesInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Céline Jahannault TalignaniInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Mélanie RousseauInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Justine GuéganData Analysis Core Platform, Institut du Cerveau - Paris Brain Institute - ICM, Sorbonne Université, INSERM, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
Yoan BuscailInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Pierrick DupréInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Henri-Alexandre MichaudInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Geneviève RodierInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Floriant BellvertMetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.ORCID 0000-0002-3259-8655
Hanna KulykMetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France.
Carole Ferraro PeyretUniv. Lyon, Claude Bernard University, LBTI UMR CNRS 5305, Faculty of Pharmacy, Lyon, France.
Hugo MathieuInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Pierre CloseLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, 4000, Liège, Belgium.ORCID 0000-0002-8844-9616
Francesca RapinoLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, 4000, Liège, Belgium.ORCID 0000-0002-4343-3805
Cédric ChaverouxUniv. Lyon, Claude Bernard University, LBTI UMR CNRS 5305, Faculty of Pharmacy, Lyon, France.
Nelly PirotInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Lucie RubioInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Adeline TorroInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Tania SorgUniversité de Strasbourg, CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), Illkirch, France.ORCID 0000-0001-6974-4735
Fabrice AngoInstitut des Neurosciences de Montpellier, Université de Montpellier, INSERM, CNRS, Montpellier, France.ORCID 0000-0002-5548-209X
Christophe HirtzIRMB-PPC, Univ. Montpellier, INSERM, CHU Montpellier, CNRS, Montpellier, France.ORCID 0000-0002-7313-0629
Vincent CompanInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.ORCID 0000-0001-6805-1179
Elise LebigotBiochemistry Department, Bicêtre Hospital, APHP Paris Saclay, Le Kremlin Bicêtre, France.ORCID 0000-0003-0419-8547
Andrea LegatiUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0002-8178-6126
Daniele GhezziUnit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0002-6564-3766
Laurent NguyenLaboratory of Molecular Regulation of Neurogenesis, GIGA Institute, University of Liège, CHU Sart Tilman, 4000, Liège, Belgium.ORCID 0000-0002-8560-3008
Alexandre DavidInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Claude SardetInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Matthieu LacroixInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France. matthieu.lacroix@inserm.fr.ORCID 0000-0002-1268-9058
Laurent Le CamInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France. laurent.lecam@inserm.fr.ORCID 0000-0003-0325-878X

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-PyrE4FLigue Contre le Cancer Equipe labélisée
6 · The paper itself

Abstract

Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that plays an essential role during brain development. Using genetically engineered mouse model and primary neuronal cells, we identify the transcription factor E4F1 as a key coordinator of AcetylCoenzyme A (AcCoA) production by the pyruvate dehydrogenase complex (PDC) and its utilization as an essential co-factor by the Elongator complex to acetylate tRNAs at the wobble position uridine 34 (U

Indexed as

BrainPyruvic AcidAnimalsBasic-Leucine Zipper Transcription FactorsDihydrolipoyllysine-Residue AcetyltransferaseFemaleGene Expression Regulation, DevelopmentalHistone AcetyltransferasesHumansLeigh DiseaseMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeuronsProtein BiosynthesisBasic-Leucine Zipper Transcription FactorsDihydrolipoyllysine-Residue AcetyltransferaseELP3 protein, humanHistone AcetyltransferasesNerve Tissue ProteinsPyruvate Dehydrogenase ComplexPyruvic AcidRNA, TransferUridine

Identifiers

PMID39747033
PMCPMC11696611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.