Evidence map›Paper›PMID 39747026›Full record

ArticleNature communications2025

Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.

Leonhard Waschke, Fabian Kamp, Evi van den Elzen, Suresh Krishna, Ulman Lindenberger, Ueli Rutishauser, Douglas D Garrett

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Leonhard Waschke *Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany.
Fabian Kamp *Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany.
Evi van den ElzenTilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.ORCID 0000-0003-4325-2497
Suresh KrishnaDepartment of Physiology, McGill University, Montreal, Canada.
Ulman LindenbergerMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany.ORCID 0000-0001-8428-6453
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-9207-7069
Douglas D GarrettMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany. garrett@mpib-berlin.mpg.de.ORCID 0000-0002-0629-7672

Funding

Neuronal mechanisms of human episodic memoryU01NS117839 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2020 to 2024
$7.8M
Deutsche Forschungsgemeinschaft (German Research Foundation) Emmy Noether grantNINDS NIH HHS U01 NS117839
6 · The paper itself

Abstract

During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

Indexed as

Action PotentialsHippocampusMemoryModels, NeurologicalNeuronsAdultComputer SimulationFemaleHumansMaleYoung Adult

Identifiers

PMID39747026
PMCPMC11696175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.