Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Chrystian Junqueira Alves *Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. chrystian.junqueira-alves@mssm.edu.ORCID 0000-0003-2224-0729
Theodore HannahNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-6527-9725
Sita SadiaNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-4414-9187
Christy KolsteegNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Angela DixonDepartment of Biology, College of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Robert J WienerCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-5238-1659
Ha NguyenNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0012-8381
Murray J TippingMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, USA.ORCID 0000-0001-5262-2723
Júlia Silva LadeiraDepartment of Computer Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Paula Fernandes da Costa FranklinDepartment of Computer Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.ORCID 0009-0008-7481-1689
Nathália de Paula Dutra de NigroDepartment of Computer Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.ORCID 0009-0004-4213-5672
Rodrigo Alves DiasDepartment of Physics, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Priscila V Zabala CaprilesDepartment of Computer Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
José P Rodrigues Furtado de MendonçaDepartment of Physics, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Paul A SlesingerNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-3868-7528
Kevin D CostaCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hongyan Zou *Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. hongyan.zou@mssm.edu.ORCID 0000-0003-4216-5607
Roland H Friedel *Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. roland.friedel@mssm.edu.ORCID 0000-0002-7513-3604
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Plexin-B2 function in glioma invasion and glioma stem cell maintenanceR01NS092735 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST · 2016 to 2025
$4.1M
Dissect governing factors for tumor stem cell dormancy in biomimetic vascular/GBM modelR01NS107462 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAI, GUOHAO, FRIEDEL, ROLAND HORST · 2018 to 2022
$3.0M
Mapping Immune Contexture and Crosstalk with Tumor Cells At GBM MarginR01NS134159 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAMBARDZUMYAN, DOLORES, ZOU, HONGYAN JENNY · 2023 to 2025
$2.0M
Leica TCS SP8 STED3XS10OD021838 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L · 2017 to 2017
$1.2M
Generation of Neurons by Force-Mediated Epigenetic Mechanisms through Manipulation of Intrinsic MechanoregulatorsK01NS127948 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUNQUEIRA ALVES, CHRYSTIAN · 2023 to 2025
$961k
Novel Mechanisms of Confined Migration of GBM CellsR21NS134158 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST · 2024 to 2025
$480k
Integrated AFM and Real-Time Confocal Microscope CoreS10RR027609 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COSTA, KEVIN D · 2010 to 2010
$469k
Tracing Hypoxic State and Hypoxia Memory in Glioblastoma ProgressionR21NS125700 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST, ZOU, HONGYAN JENNY · 2022 to 2023
$465k
NCI NIH HHS P30 CA008748NCRR NIH HHS S10 RR027609New York State Department of Health (NYS Department of Health) C38330GGNew York State Department of Health (NYS Department of Health) C39068GGNIH HHS S10 OD021838NINDS NIH HHS K01 NS127948NINDS NIH HHS R01 NS092735NINDS NIH HHS R01 NS107462NINDS NIH HHS R01 NS134159NINDS NIH HHS R21 NS125700NINDS NIH HHS R21 NS134158U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS092735U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS107462U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS125700U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS127948U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS134159
6 · The paper itself
Abstract
Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space. Using live-cell imaging to track GBM cells negotiating microchannels, we reveal endocytic vesicle accumulation at cell front and filamentous actin assembly at cell rear in a polarized manner. These processes are interconnected and require Plexin-B2 signaling. We further show that Plexin-B2 governs membrane tension and other membrane features such as endocytosis, phospholipid composition, and inner leaflet surface charge, thus providing biophysical mechanisms by which Plexin-B2 promotes GBM invasion. Together, our studies unveil how GBM cells regulate membrane tension and mechano-electrical coupling to adapt to physical constraints and achieve polarized confined migration.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2. · full record | OpenQuestion