ArticleNature communications2025
Genomic signatures of adaptation in native lizards exposed to human-introduced fire ants.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Widespread male-female expression imbalance of X-linked genes across phrynosomatid lizards.Molecular biology and evolution · 2026Article
- Genotype-Phenotype-Environment Associations and Potential Local Adaptation Signals in the Mesquite Lizard Along the Eastern Trans-Mexican Volcanic Belt.Molecular ecology · 2026Article
- Climate-induced patterns of activity and nest conditions select for genes associated with growth and maturation in a widespread lizard species.Research square · 2026Article
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Authors and funding
8 authors.
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Abstract
Understanding the process of genetic adaptation in response to human-mediated ecological change will help elucidate the eco-evolutionary impacts of human activity. In the 1930s red imported fire ants (Solenopsis invicta) were accidently introduced to the Southeastern USA, where today they are both venomous predators and toxic prey to native eastern fence lizards (Sceloporus undulatus). Here, we investigate potential lizard adaptation to invasive fire ants by generating whole-genome sequences from 420 lizards across three populations: one with long exposure to fire ants, and two unexposed populations. Signatures of positive selection exclusive to the exposed population overlap immune system, growth factor pathway, and morphological development genes. Among invaded lizards, longer limbs (used to remove stinging ants) are associated with increased survival. We identify alleles associated with longer limbs that are highly differentiated from the unexposed populations, a pattern counter to the pre-invasion latitudinal cline for limb lengths based on museum specimens. While we cannot rule out other environmental differences between populations driving these patterns, these results do constitute plausible genetic adaptations in lizards invaded by fire ants.
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