Evidence map›Paper›PMID 39746892›Full record

ReviewDigestive diseases and sciences2025

Trends in Mortality Due to Inflammatory Bowel Disease in the United States: A CDC WONDER Database Analysis (1999-2020).

Syed Sarmad Javaid, Shanzay Akhtar, Areesha Hafeez, Abdullah Nofal, Sara Rahman, Sabeeh Khawar Farooqui, Mushood Ahmed, Ifra Eeman Ahmed, Saba Fatima, Hira Javaid and 6 more

Abstract readReview
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In one paragraph

Review in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Syed Sarmad JavaidDepartment of Medicine, University of Mississippi Medical Center, Jackson, USA. ssjavaid@umc.edu.
Shanzay AkhtarKarachi Medical and Dental College, Karachi, Pakistan.
Areesha HafeezKarachi Medical and Dental College, Karachi, Pakistan.
Abdullah NofalServices Institute of Medical Sciences, Lahore, Pakistan.
Sara RahmanServices Institute of Medical Sciences, Lahore, Pakistan.
Sabeeh Khawar FarooquiZiauddin University, Karachi, Pakistan.
Mushood AhmedRawalpindi Medical University, Rawalpindi, Pakistan.
Ifra Eeman AhmedFederal Medical and Dental College, Islamabad, Pakistan.
Saba FatimaJinnah Sindh Medical University, Karachi, Pakistan.
Hira JavaidAllama Iqbal Medical College Lahore, Lahore, Pakistan.
Kantash KumarInternal Medicine Maimonides Medical Center, New York, USA.
Harjinder SinghSahiwal Teaching Hospital, Sahiwal, Pakistan.
Mishall Ahmed BaigDow Medical College, Karachi, Pakistan.
Ahmed Ali AzizDepartment of Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA.
Ashujot K DangDepartment of Internal Medicine, University of California Riverside School of Medicine, Riverside, USA.
Muhammad Shikaib ShabbirDepartment of Internal Medicine, University of California Riverside School of Medicine, Riverside, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInflammatory bowel disease (IBD) is a global health issue profoundly impacting quality of life. The United States accounts for nearly a quarter of the world's IBD patients, with the highest prevalence rates. This study aims to identify the demographic and regional trends of IBD-related mortality in the U.S. from 1999 to 2020. METHODOLOGY: Our study utilized the CDC Wonder database to gather mortality data for IBD (Crohn's disease and ulcerative colitis) from 1999 to 2020. Results were presented as age-adjusted mortality rates (AAMR) per 100,000 population, with Joinpoint regression used to analyze trend changes and calculate annual percentage change (APC).

resultsA total of 62,310 IBD-related deaths were recorded. From 1999 to 2020, AAMR for Crohn's disease increased from 0.79 to 0.97, declining from 1999 to 2018 (APC: - 0.22) but surging from 2018 onwards (APC: 11.26). Women had a higher AAMR (0.81) compared to men (0.77). The highest rates were among non-Hispanic whites (0.86), followed by non-Hispanic blacks (0.48) and Hispanics (0.21). AAMR varied by state, ranging from 0.29 in Hawaii to 1.42 in Vermont. For ulcerative colitis, AAMR rose from 0.56 in 1999 to 0.63 in 2020, following a similar trend: a decline from 1999 to 2018 (APC: - 0.37) followed by an increase (APC: 12.21). State-specific AAMR ranged from 0.14 in Hawaii to 0.67 in Oregon.

conclusionThis study highlights a decrease in AAMR for both diseases from 1999 to 2018, followed by significant increases from 2018 to 2020, indicating a need for targeted interventions.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesAdolescentAdultAgedCenters for Disease Control and Prevention, U.S.Databases, FactualFemaleHumansMaleMiddle AgedMortalityUnited StatesYoung AdultCrohn’s diseaseInflammatory bowel diseaseMortalityUlcerative colitis

Identifiers

PMID39746892

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.