Evidence map›Paper›PMID 39746885›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Phase-Separated Spiropyran Coacervates as Dual-Wavelength-Switchable Reactive Oxygen Generators.

Hao Kong, Xian Xie, Yishu Bao, Fang Zhang, Liming Bian, Kai Cheng, Yuan-Di Zhao, Jiang Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao KongDepartment of Chemistry, The Chinese University of Hong Kong, Shatin, 99999, Hong Kong SAR, China.
Xian XieDepartment of Chemistry, The Chinese University of Hong Kong, Shatin, 99999, Hong Kong SAR, China.
Yishu BaoDepartment of Chemistry, The Chinese University of Hong Kong, Shatin, 99999, Hong Kong SAR, China.
Fang ZhangBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, P. R. China.
Liming BianSchool of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, P.R. China.
Kai ChengDepartment of Chemistry, The Chinese University of Hong Kong, Shatin, 99999, Hong Kong SAR, China.
Yuan-Di ZhaoBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, P. R. China.
Jiang XiaDepartment of Chemistry, The Chinese University of Hong Kong, Shatin, 99999, Hong Kong SAR, China.ORCID 0000-0001-8112-7625

Funding

CUHK (ICSG, CRIMS, and Direct Grant) 4053563National Natural Science Foundation of China 62305121Research Impact Fund R5013-19University Grants Committee GRF grants 14304921, 14306222, and 14307523
6 · The paper itself

Abstract

Low-molecular-weight compounds of certain structural features may form coacervates through liquid-liquid phase separation (LLPS). These coacervates can enter mammalian cells and affect cellular physiology. Controlling the properties of the coacervates inside cells, however, is a challenge. Here, we report photochemical reactions of spiropyran (SP)-based coacervates with two wavelengths of light, in vitro, in the cell, and in animals, generating reactive oxygen species (ROS) for photo-controlled cell killing. We identify an SP-containing compound, SP-PEG

Indexed as

BenzopyransIndolesNitro CompoundsReactive Oxygen SpeciesAnimalsCell SurvivalHumansMiceMolecular StructurePhotosensitizing AgentsUltraviolet RaysBenzopyransIndolesmerocyanineNitro CompoundsPhotosensitizing AgentsReactive Oxygen Speciesspiropyrancoacervatesliquid-liquid phase seperationphotodynamic therapyreactive oxygen speciesSpiropyran

Identifiers

PMID39746885
PMCPMC11833283

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.