Evidence map›Paper›PMID 39746882›Full record

Observational studyJournal of endocrinological investigation2025

Influence of androgen receptor on bone health in transgender adults: insights from the COMET study.

Chiara Ceolin, Alberto Scala, Maria Santa Rocca, Bianca Scagnet, Massimiliano Marton, Cristina Simonato, Chiara Ziliotto, Marina De Rui, Valentina Camozzi, Sandro Giannini and 6 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Impact of reference gender on bone mineral density and fracture risk assessment in transgender adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chiara Ceolin *Geriatrics Division, Department of Medicine (DIMED), University of Padua, Padua, Italy. chiara.ceolin.1@phd.unipd.it.
Alberto Scala *Regional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Maria Santa RoccaUnit of Andrology and Reproductive Medicine, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Bianca ScagnetUnit of Andrology and Reproductive Medicine, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Massimiliano MartonUnit of Andrology and Reproductive Medicine, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Cristina SimonatoGeriatrics Division, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Chiara ZiliottoGeriatrics Division, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Marina De RuiGeriatrics Division, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Valentina CamozziRegional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Sandro GianniniRegional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Daniela BassoRegional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Giulia MussoRegional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Alberto FerlinRegional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Giuseppe SergiGeriatrics Division, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Andrea GarollaRegional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Gender IncongruenceInterdisciplinary Group (GIIG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies show that transgender and gender-diverse (TGD) individuals, especially those assigned male at birth (AMAB), often have low bone mineral density (BMD) before beginning gender-affirming hormone therapy (GAHT). The reasons for this are not fully understood, and the potential role of androgen receptor (AR) polymorphisms - known to affect bone density in the general population - has not been explored. This study aims to assess the impact of AR polymorphisms on bone health in the TGD population.

methodsThis is an observational study involving 135 TGD and 107 cisgender participants. Collected data included hormonal profiles and phospho-calcium metabolism, bone geometry and density (Dual Energy X-ray Absorptiometry and peripheral Quantitative Computed Tomography). For the genetic study related to the AR, genomic DNA was extracted from peripheral blood leukocytes.

resultsTGD individuals had lower BMD values compared to their cisgender peers. In a subgroup of 129 individuals (86 TGD and 43 cisgender), we assessed the length of the polymorphic tracts of the AR gene and observed no differences between the groups. AR polymorphisms showed significant correlations only with cortical BMD in both TGD and cisgender assigned females at birth (AFAB) individuals, and negative correlations with trabecular BMD in both cisgender men and women.

conclusionsOur study suggests that AR polymorphisms do not play a significant role in the low BMD values observed in TGD individuals at baseline. Further research is necessary to better understand the impact of factors such as lifestyle on the bone health of TGD individuals.

Indexed as

Bone DensityReceptors, AndrogenTransgender PersonsAbsorptiometry, PhotonAdultFemaleHumansMaleMiddle AgedPolymorphism, GeneticYoung AdultAR protein, humanReceptors, AndrogenAndrogen receptorBone geometryBone mineral densityGeneticsTransgender

Identifiers

PMID39746882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.