Evidence map›Paper›PMID 39746820›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Dopamine Boosts Motivation for Prosocial Effort in Parkinson's Disease.

Jamie Talbot, Jo Cutler, Marin Tamm, Simon J Little, Catherine J Harmer, Masud Husain, Patricia L Lockwood, Matthew A J Apps

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05065151 (Understanding Motivation in Parkinson's Patients Through Neurophysiology), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05065151 narecruitingnot on this map

Understanding Motivation in Parkinson's Patients Through Neurophysiology

TypeinterventionalSponsorUniversity of California, San FranciscoRan2021 to 2030Enrolled70ConditionsParkinson Disease, Deep Brain Stimulation, MotivationArmsStimulation on, Stimulation off, Decision Making Task
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Central Questions for Social Neuroscience Research.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jamie TalbotCentre for Human Brain Health, School of Psychology University of Birmingham, Birmingham B15 2TT, United Kingdom jxt289@student.bham.ac.uk m.a.j.apps@bham.ac.uk.ORCID https://orcid.org/0000-0002-4720-1972
Jo CutlerCentre for Human Brain Health, School of Psychology University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID https://orcid.org/0000-0003-1073-764X
Marin TammDepartment of Experimental Psychology, University of Oxford, Oxford OX2 6GG, United Kingdom.
Simon J LittleDepartment of Neurology, University of California, San Francisco, California 94143.
Catherine J HarmerDepartment of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom.
Masud HusainDepartment of Experimental Psychology, University of Oxford, Oxford OX2 6GG, United Kingdom.ORCID https://orcid.org/0000-0002-6850-9255
Patricia L LockwoodCentre for Human Brain Health, School of Psychology University of Birmingham, Birmingham B15 2TT, United Kingdom.
Matthew A J AppsCentre for Human Brain Health, School of Psychology University of Birmingham, Birmingham B15 2TT, United Kingdom jxt289@student.bham.ac.uk m.a.j.apps@bham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being willing to exert effort to obtain rewards is a key component of motivation. Previous research has shown that boosting dopamine can increase the willingness to choose to exert effort to obtain rewards for ourselves. Yet often we must choose whether to exert effort, not for our own immediate benefit, but to be prosocial and obtain a benefit for someone else. Pharmacologically increasing dopamine availability has been shown to change social behaviors in experimental tasks, and dopamine degeneration in Parkinson's disease (PD) impacts a range of sociocognitive processes. However, the neuromodulators involved in deciding whether to exert effort to benefit others are unknown. Does dopamine modulate the willingness to exert prosocial effort? Here, male and female PD patients (

Indexed as

dopamineeffort-based decision-makingmotivationParkinson's diseaseprosocial motivation

Identifiers

PMID39746820
PMCPMC12940455

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.