ArticleRenal failure2025
Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Creatinine-to-cystatin C ratio as muscle assessment tool and predictive value for mortality and sarcopenia in patients with chronic kidney disease: a meta-analysis.Frontiers in nutrition · 2025Pooled it
- Pilot Study of Diagnostic Performance of Serum Creatinine/Cystatin C Ratio for Pseudo-AKI.Kidney international reports · 2026Article
- Correlation Between Serum Creatinine-to-Cystatin C Ratio and Prognosis of Patients with Hip Fracture.International journal of general medicine · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBoth serum creatinine and cystatin C serve as dependable markers of renal function and have demonstrated a correlation with clinical outcomes in diverse conditions, particularly through the ratio of creatinine to cystatin C (Cr/CysC). Anuric patients undergoing peritoneal dialysis (PD) depend entirely on the clearance of peritoneal solutes. This research posits that the Cr/CysC ratio may predict all-cause mortality and technique failure in anuric PD patients.
methodsA cohort of 224 anuric PD patients was recruited from January 1, 2014, to December 31, 2019, with follow-up extending until December 31, 2023. The Cr/CysC ratio was computed by dividing the serum creatinine concentration by the cystatin C concentration obtained on the same day. We evaluated the relationship between the Cr/CysC ratio and patient survival, as well as technique failure, utilizing Cox regression and competing risk analyses.
resultsThe average age of the participants was 50.46 ± 12.63 years, with 99 individuals (44.2%) being male. Among all subjects, the Cr/CysC ratio was found to be 1.85 ± 0.56. After controlling for potential confounders, Cox proportional hazards models revealed that the Cr/CysC ratio was significantly linked to the risk of all-cause mortality and technique failure (HR = 0.330, 95% CI 0.124-0.881,
conclusionThe Cr/CysC ratio at baseline was recognized as an independent predictor of all-cause mortality and technique failure in anuric PD patients.
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