Evidence map›Paper›PMID 39746572›Full record

ArticleThe Journal of investigative dermatology2025

Epidermal Penetration Increases with Age and May Contribute to Systemic Inflammation.

T Richard Parenteau, Anna Celli, Jiechen Zhang, Jeanmarie Gonzalez, Jason M Meyer, Brook Abegaze, Merisa L Piper, Peter M Elias, Katrina Abuabara, Carl Grunfeld and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Demographic factors associated with skin barrier function in a large population-based study.JID innovations : skin science from molecules to population health · 2026
    Article
  2. Polymeric Nanogels for Skin Applications.Gels (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

T Richard ParenteauDivision of Geriatrics, University of California, San Francisco, San Francisco, California, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, California, USA.
Anna CelliDermatology Service, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Jiechen ZhangDepartment of Dermatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jeanmarie GonzalezBiomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California, USA.
Jason M MeyerDepartment of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Brook AbegazeDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Merisa L PiperDivision of Plastic and Reconstructive Surgery, University of California, San Francisco, San Francisco, California, USA.
Peter M EliasDermatology Service, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Katrina AbuabaraDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Carl GrunfeldDermatology Service, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Mao-Qiang ManDermatology Service, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
Tiffany C ScharschmidtDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Theodora M MauroDermatology Service, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA; Department of Dermatology, University of California, San Francisco, San Francisco, California, USA. Electronic address: thea.mauro@ucsf.edu.

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
RESEARCH TRAINING IN GERIATRIC MEDICINET32AG000212 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 1991 to 2026
$7.7M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Pathogenesis and Therapy of Ichthyosis in Disorders of Lipid MetabolismR01AR061106 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2012 to 2022
$3.3M
BLRD VA I01 BX006094NCI NIH HHS P30 CA082103NIAID NIH HHS T32 AI007334NIAID NIH HHS T32 AI060537NIAMS NIH HHS R01 AR061106NIA NIH HHS T32 AG000212
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingEpidermal barrierInflammagingOcclusionPermeability

Identifiers

PMID39746572
PMCPMC12103278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.