Evidence map›Paper›PMID 39746412›Full record

ArticleNeuroImage2025

Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T.

Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L Dawson and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kexin WangF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Licheng JuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Guanda QiaoDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Yajie LiangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Yihan WuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Chengyan ChuDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Joshua RogersDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Yuguo LiF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Suyi CaoNeuroregeneration and Stem Cell Programs, The Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Valina L DawsonNeuroregeneration and Stem Cell Programs, The Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ted M DawsonNeuroregeneration and Stem Cell Programs, The Institute of Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Piotr WalczakDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Jiadi XuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jxu37@jh.edu.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
IN VIVO MURINE CARDIAC ENERGY METABOLISM AND FUNCTIONR01HL063030 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2000 to 2018
$4.9M
Cerebrospinal fluid exchange in Alzheimer's disease characterized by advanced MRI techniquesR01AG080104 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI JIadi Xu · 2023 to 2026
$2.9M
MRI based phosphocreatine mapping method to assess patients with peripheral arterial disease.R01HL149742 · NHLBI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Michael Schaer, JIadi Xu · 2020 to 2026
$2.5M
Altered pH in early Alzheimer's disease detected by creatine chemical exchange saturation transfer MRIR21AG074978 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI XU, JIADI · 2022 to 2022
$444k
NHLBI NIH HHS R01 HL063030NHLBI NIH HHS R01 HL149742NIA NIH HHS R01 AG080104NIA NIH HHS R21 AG074978NIBIB NIH HHS P41 EB031771
6 · The paper itself

Abstract

This study aims to investigate the variations in guanidino (Guan), amine and amide chemical exchange saturation transfer (CEST) contrasts in ischemic stroke using permanent middle cerebral artery occlusion (pMCAO) and transient MCAO (tMCAO) models at high (9.4T) and clinical (3T) MRI fields. CEST contrasts were extracted using the Polynomial and Lorentzian Line-shape Fitting (PLOF) method. Both pMCAO and tMCAO models were utilized to examine the B

Indexed as

AminesBrainIschemic StrokeMagnetic Resonance ImagingStrokeAmidesAnimalsHydrogen-Ion ConcentrationInfarction, Middle Cerebral ArteryMaleRatsAmidesAminesAmideCESTAmine CEST (amineCEST)Arginine CEST (ArgCEST)Chemical Exchange Saturation Transfer (CEST)Creatine CEST (CrCEST)Creatine mappingGuanidino or guanidinium CEST (GuanCEST)Permanent middle cerebral artery occlusion (pMCAO)pH mappingPolynomial Lorentzian Line-shape Fitting (PLOF)ReperfusionStrokeTransient middle cerebral artery occlusion (tMCAO)

Identifiers

PMID39746412
PMCPMC12395395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.