Observational studyNeonatology2025
Association between Enteral Protein Intake and Fat-Free Mass Accretion in Very Preterm Infants.
Observational study in Neonatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Fat-free mass is associated with neurodevelopment outcomes in extremely preterm infants up to 3 years of age.Pediatric research · 2026Article
- Human milk macronutrient composition and intake in relation to preterm infant growth: a cohort study.Clinical and experimental pediatrics · 2026Article
- Amino acids and lean mass accretion in preterm neonates.Current opinion in clinical nutrition and metabolic care · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionFor preterm infants, the first 2 weeks after birth are a time when nutrition and protein intake is variable and often falls below recommended intakes. Our objective was to investigate the relationship between protein intake, including source of protein, during the first 2 weeks after birth and fat-free mass (FFM) accretion in a group of very preterm infants.
methodsIn this observational cohort study, body composition was assessed using air displacement plethysmography in eligible infants <32 weeks gestational age at 2 weeks after birth and prior to discharge. FFM accretion was calculated as difference between the two measurements. We collected daily nutrition data for the first 2 weeks. Multivariable linear regression was used to assess the relationship between protein intake and body composition and weight gain.
resultsSeventy-eight infants were included (mean birthweight: 1,408±278 g). Mean cumulative protein intake of this cohort in the first 2 weeks was 2.4±0.8 g/kg/day of which 74±19% was enteral (1.7±0.6 g/kg/day). Enteral protein intake was associated with higher FFM while parenteral protein was associated with lower FFM. Total protein intake from both sources during the first 2 weeks after birth was positively associated with greater weight gain.
conclusionEnteral protein intake during the first 2 weeks after birth is associated with higher FFM and weight in preterm infants. Future interventional studies should investigate the effects of higher enteral protein intake during the first 2 weeks after birth on growth and body composition.
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Registered trials
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