Evidence map›Paper›PMID 39746338›Full record

ArticleBlood purification2025

Innovation of a Neonatal Peritoneal Dialysis Catheter to Expand Dialysis Capabilities for Critically Ill Neonates in Low-Resource Settings.

Sergio Ruiz Vega, Carl Russell Lll, Siting Zhang, Mignon McCulloch, Aaron Lottes, Hyowon Lee, Danielle E Soranno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood purification, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sergio Ruiz VegaWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Carl Russell LllWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Siting ZhangWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Mignon McCullochRed Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Aaron LottesWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Hyowon LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.
Danielle E SorannoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe lack of peritoneal dialysis (PD) catheters designed explicitly for neonates creates significant challenges in the provision of neonatal PD. High resource settings can circumvent this limitation by resorting to alternative extracorporeal dialysis methods. However, in low-resource settings, PD remains the preferred dialysis modality, and the use of off-label catheters for PD results in complications such as omental wrapping and occlusion. This study introduces a novel catheter design featuring a multi-diameter side port configuration and a helical geometry.

methodsWe employed numerical simulations to identify an optimal multi-diameter side port configuration, to address fluid dynamic issues that lead to catheter occlusion and omental wrapping. Following the simulations, we experimentally evaluated the catheter's performance in a series of benchtop tests designed to simulate physiological conditions encountered in neonatal PD.

resultsOur experimental evaluations demonstrated that the helical catheter outperforms commonly utilized pigtail catheters with same-sized diameter side ports by consistently achieving superior drainage efficiency during fibrin clot occlusion and omental wrapping tests.

conclusionThe catheter is intended to be placed at the bedside to perform renal replacement therapy for neonates in low-resourced settings.

introductionThe lack of peritoneal dialysis (PD) catheters designed explicitly for neonates creates significant challenges in the provision of neonatal PD. High resource settings can circumvent this limitation by resorting to alternative extracorporeal dialysis methods. However, in low-resource settings, PD remains the preferred dialysis modality, and the use of off-label catheters for PD results in complications such as omental wrapping and occlusion. This study introduces a novel catheter design featuring a multi-diameter side port configuration and a helical geometry.

methodsWe employed numerical simulations to identify an optimal multi-diameter side port configuration, to address fluid dynamic issues that lead to catheter occlusion and omental wrapping. Following the simulations, we experimentally evaluated the catheter's performance in a series of benchtop tests designed to simulate physiological conditions encountered in neonatal PD.

resultsOur experimental evaluations demonstrated that the helical catheter outperforms commonly utilized pigtail catheters with same-sized diameter side ports by consistently achieving superior drainage efficiency during fibrin clot occlusion and omental wrapping tests.

conclusionThe catheter is intended to be placed at the bedside to perform renal replacement therapy for neonates in low-resourced settings.

Indexed as

CathetersPeritoneal DialysisCritical IllnessEquipment DesignHumansInfant, NewbornLow- and middle-income countriesNeonatal acute kidney injuryPeritoneal dialysis

Identifiers

PMID39746338
PMCPMC11949190

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.