Evidence map›Paper›PMID 39745972›Full record

ArticleScience (New York, N.Y.)2025

Competitive social feedback amplifies the role of early life contingency in male mice.

Matthew N Zipple, Daniel Chang Kuo, Xinmiao Meng, Tess M Reichard, Kwynn Guess, Caleb C Vogt, Andrew H Moeller, Michael J Sheehan

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. But What Behavior?ArXiv · 2026
    Article
  4. Article
  5. The Sikkim mouse (bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Matthew N ZippleDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-3451-2103
Daniel Chang KuoDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.ORCID 0009-0004-5061-3523
Xinmiao MengDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Tess M ReichardDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Kwynn GuessDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Caleb C VogtDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-9315-3775
Andrew H MoellerDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-8377-4647
Michael J SheehanDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-3949-7873

Funding

Uncovering the modes and genetics of gut bacterial transmissionR35GM138284 · NIGMS · PRINCETON UNIVERSITY · PI Andrew Moeller · 2020 to 2026
$2.4M
The genomics and consequences of gut bacterial adaptation to high-fat dietsR01DK139214 · NIDDK · PRINCETON UNIVERSITY · PI Andrew Moeller · 2024 to 2026
$1.3M
NIDDK NIH HHS R01 DK139214NIGMS NIH HHS R35 GM138284
6 · The paper itself

Abstract

Contingency (or "luck") in early life plays an important role in shaping individuals' development. By comparing the developmental trajectories of functionally genetically identical free-living mice who either experienced high levels of resource competition (males) or did not (females), we show that competition magnifies early contingency. Male resource competition results in a feedback loop that magnifies the importance of early contingency and pushes individuals onto divergent, self-reinforcing life trajectories, while the same process appears absent in females. Our results indicate that the strength of sexual selection may be self-limiting, and they highlight the potential for contingency to lead to differences in life outcomes, even in the absence of any underlying differences in ability ("merit").

Indexed as

Competitive BehaviorAnimalsFemaleMaleMiceMice, Inbred C57BLSexual SelectionSocial Behavior

Identifiers

PMID39745972
PMCPMC12978263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.