Evidence map›Paper›PMID 39745931›Full record

ArticleACS chemical biology2025

Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro.

Kevin Li, Yae In Cho, Mai Anh Tran, Christoph Wiedemann, Shuaibing Zhang, Rebecca S Koweek, Ngọc Khánh Hoàng, Grayson S Hamrick, Margaret A Bowen, Bashkim Kokona and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. RSC chemical biology · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kevin LiDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.
Yae In ChoDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.ORCID 0000-0002-0503-5486
Mai Anh TranFaculty of Chemistry and Earth Sciences, Institute for Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
Christoph WiedemannFaculty of Chemistry and Earth Sciences, Institute for Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0003-4351-8857
Shuaibing ZhangDepartment of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany.ORCID 0000-0003-4455-0971
Rebecca S KoweekDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.
Ngọc Khánh HoàngDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.
Grayson S HamrickDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.ORCID 0000-0002-3149-538X
Margaret A BowenDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.
Bashkim KokonaDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.
Pierre StallforthFaculty of Chemistry and Earth Sciences, Institute for Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0001-7260-9921
Joris BeldDepartment of Microbiology & Immunology, Center for Advanced Microbial Processing, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-7070-663X
Ute A HellmichFaculty of Chemistry and Earth Sciences, Institute for Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0001-7162-285X
Louise K CharkoudianDepartment of Chemistry, Haverford College, Haverford, Pennsylvania 19041, United States.ORCID 0000-0002-4342-2815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial polyketides represent a structurally diverse class of secondary metabolites with medicinally relevant properties. Aromatic polyketides are produced by type II polyketide synthase (PKS) systems, each minimally composed of a ketosynthase-chain length factor (KS-CLF) and a phosphopantetheinylated acyl carrier protein (

Indexed as

Acyl Carrier ProteinPolyketide SynthasesProtein EngineeringBacillus subtilisBacterial ProteinsCyanobacteriaEscherichia coliTransferases (Other Substituted Phosphate Groups)Acyl Carrier ProteinBacterial Proteinsphosphopantetheinyl transferasePolyketide SynthasesTransferases (Other Substituted Phosphate Groups)

Identifiers

PMID39745931
PMCPMC11744666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.