Evidence map›Paper›PMID 39745465›Full record

ArticleJournal of virology2025

Induction of PD-1 and CD44 in CD4

Sharda Kumari, Ankit Biswas, Tushar Kanti Maiti, Bhaswati Bandyopadhyay, Arup Banerjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharda KumariLaboratory of Virology, Regional Centre for Biotechnology, National Capital Region Biotechnology Science Cluster, Faridabad, Haryana, India.
Ankit BiswasFunctional Proteomics Laboratory, Regional Centre for Biotechnology, National Capital Region Biotechnology Science Cluster, Faridabad, Haryana, India.
Tushar Kanti MaitiFunctional Proteomics Laboratory, Regional Centre for Biotechnology, National Capital Region Biotechnology Science Cluster, Faridabad, Haryana, India.
Bhaswati BandyopadhyayDepartment of Microbiology, School of Tropical Medicine, Kolkata, West Bengal, India.
Arup BanerjeeLaboratory of Virology, Regional Centre for Biotechnology, National Capital Region Biotechnology Science Cluster, Faridabad, Haryana, India.ORCID 0000-0002-0600-1763

Funding

Indian Council of Medical Research (ICMR) EMDR/ SG/ 9/ 2023-2364University Grants Commission (UGC) DEC18-319539
6 · The paper itself

Abstract

Extracellular vesicles (EVs) emerged as critical contributors to the pathogenesis of vascular endothelial barrier dysfunction during the inflammatory response to infection. However, the contribution of circulating EVs to modifying endothelial function during dengue virus infection remains unclear. In this study, we showed that severe dengue patients' plasma-derived EV (SD-EV) were found to carry elevated levels of different protein cargos, e.g., immunoregulatory proteins (PD-L1, CD44). Further, we demonstrated that SD-EV induces PD-1 and CD44 expression on CD4

Indexed as

CD4-Positive T-LymphocytesExtracellular VesiclesHyaluronan ReceptorsNF-kappa BProgrammed Cell Death 1 ReceptorSevere DengueB7-H1 AntigenDengue VirusEndothelial CellsHumansIntercellular Adhesion Molecule-1MaleSignal TransductionB7-H1 AntigenCD274 protein, humanCD44 protein, humanHyaluronan ReceptorsICAM1 protein, humanIntercellular Adhesion Molecule-1NF-kappa BPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCD44endothelial cellsextracellular vesiclesPD-L1 dengue

Identifiers

PMID39745465
PMCPMC11852895

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.