Evidence map›Paper›PMID 39745446›Full record

ArticleJournal of clinical microbiology2025

Assembly and performance of a cholera RDT prototype that detects both

Md Abu Sayeed, Imrul Kayes Nabil, Piyash Bhattacharjee, Md Shawkat Hossain, Noor Jahan Akter, Romana Akter, Karen L Kelley, Mahbubul Karim, Yasmin Ara Begum, Taufiqur Rahman Bhuiyan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Md Abu SayeedDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-4256-4659
Imrul Kayes NabilInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Dhaka Division, Bangladesh.
Piyash BhattacharjeeInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Dhaka Division, Bangladesh.
Md Shawkat HossainIncepta Pharmaceuticals Ltd, Dhaka, Dhaka Division, Bangladesh.
Noor Jahan AkterIncepta Pharmaceuticals Ltd, Dhaka, Dhaka Division, Bangladesh.
Romana AkterIncepta Pharmaceuticals Ltd, Dhaka, Dhaka Division, Bangladesh.
Karen L KelleyUF-ICBR Electron Microscopy Core, Gainesville, Florida, USA.
Mahbubul KarimIncepta Pharmaceuticals Ltd, Dhaka, Dhaka Division, Bangladesh.
Yasmin Ara BegumInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Dhaka Division, Bangladesh.
Taufiqur Rahman BhuiyanInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Dhaka Division, Bangladesh.ORCID 0000-0003-3755-4763
Firdausi QadriInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Dhaka Division, Bangladesh.ORCID 0000-0002-8928-9888
Ashraful Islam KhanInfectious Diseases Division (IDD) & Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Dhaka Division, Bangladesh.
Eric J NelsonDepartment of Pediatrics, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-2649-2624

Funding

Wellcome TrustWellcome Trust (WT) DFID grant 215676/Z
6 · The paper itself

Abstract

Cholera rapid diagnostic tests (RDTs) are vulnerable to virulent bacteriophage predation. We hypothesized that an enhanced cholera RDT that detects the common virulent bacteriophage ICP1 might serve as a proxy for pathogen detection. We previously developed a monoclonal antibody (mAb) to the ICP1 major capsid protein. Our objective was to design and assemble a first-of-its-kind RDT that detects both a bacterial pathogen (

Indexed as

BacteriophagesCholeraDiagnostic Tests, RoutineVibrio choleraeAntibodies, MonoclonalCapsid ProteinsFecesHumansSensitivity and SpecificityAntibodies, MonoclonalCapsid ProteinsbacteriophageBangladeshcholeradiarrheaICP1phagerapid diagnostic testRDTVibrio choleraevibriophage

Identifiers

PMID39745446
PMCPMC11837499

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.