Evidence map›Paper›PMID 39745422›Full record

ArticleJournal of clinical microbiology2025

High-sensitivity detection of

Alaina M Olson, Rachel C Wood, Kris M Weigel, Alexander J Yan, Katherine A Lochner, Rane B Dragovich, Angelique K Luabeya, Paul Yager, Mark Hatherill, Gerard A Cangelosi

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Diagnostic Accuracy of Molecular Testing on Saliva and Oral Swabs for Pulmonary Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  3. Article
  4. Article
  5. Development of a Rapid Automated Point-of-Care Test formedRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Tongue swabmedRxiv : the preprint server for health sciences · 2026
    Article
  8. Salivary exosomalFrontiers in cellular and infection microbiology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Oral Rinse as an Alternative Diagnostic Specimen for Detection of Tuberculosis.American journal of respiratory and critical care medicine · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alaina M OlsonDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2384-5025
Rachel C WoodDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Kris M WeigelDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Alexander J YanDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Katherine A LochnerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Rane B DragovichDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Angelique K LuabeyaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Rondebosch, Western Cape, South Africa.
Paul YagerDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Mark HatherillSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Rondebosch, Western Cape, South Africa.
Gerard A CangelosiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-0006-6520

Funding

The Center for Innovation in Point-of-Care Technologies for HIV/AIDS atNorthwestern University (C-THAN) Supplemental RequestU54EB027049 · NIBIB · NORTHWESTERN UNIVERSITY · PI Kara M Palamountain · 2018 to 2026
$24.0M
Non-invasive diagnosis of adult pulmonary tuberculosisR01AI139254 · NIAID · UNIVERSITY OF WASHINGTON · PI CANGELOSI, GERARD A · 2019 to 2022
$1.3M
High-sensitivity tongue swab testing for tuberculosisR21AI185407 · NIAID · UNIVERSITY OF WASHINGTON · PI CANGELOSI, GERARD A · 2024 to 2025
$428k
Gates Foundation INV-004527HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139254, R21AI185407HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) U54EB027049NIAID NIH HHS R01 AI139254NIAID NIH HHS R21 AI185407NIBIB NIH HHS U54 EB027049
6 · The paper itself

Abstract

Tongue swab (TS) sampling combined with quantitative PCR (qPCR) to detect IMPORTANCE: Improved testing for tuberculosis (TB) is needed. Using a more accessible sample type than sputum may enable the detection of more cases, but it is critical that alternative samples be tested appropriately. Here, we describe two new, highly accurate methods for testing tongue swabs for TB DNA.

Indexed as

DNA, BacterialMycobacterium tuberculosisSpecimen HandlingTongueTuberculosisAdultFemaleHumansMaleMolecular Diagnostic TechniquesReal-Time Polymerase Chain ReactionSensitivity and SpecificitySouth AfricaSputumDNA, Bacterialdiagnosismagnetic captureqPCRswabtuberculosis

Identifiers

PMID39745422
PMCPMC11837540

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.