Evidence map›Paper›PMID 39745366›Full record

ArticlemSphere2025

A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in

Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S Chaudhari, Kenneth W Bayles, Vinai C Thomas, Rajib Saha

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. InJournal of bacteriology · 2026
    Article
  2. Review
  3. Article
  4. InbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Journal of bacteriology · 2025
    Article
  9. Growth and acetate metabolism ofApplied and environmental microbiology · 2025
    Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nabia ShahreenDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0002-6461-6184
Jongsam AhnDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Adil Alsiyabi *Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Niaz Bahar Chowdhury *Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Dhananjay ShindeDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Sujata S ChaudhariDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Kenneth W BaylesDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Vinai C ThomasDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0002-7886-0727
Rajib SahaDepartment of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0002-2974-0243

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
The role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9M
A Predictive Modeling Framework to Dissect the Dynamic Immunometabolic Responses to Pathogenic infection and the Kinetic Reprogramming of Metabolism in Cancer Cell SystemR35GM143009 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI SAHA, RAJIB · 2021 to 2025
$1.8M
National Science Foundation (NSF) CAREER 1943310Nebraska Collaborative Initiative (NCI) 21-1106-6009NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588NIGMS NIH HHS R35 GM143009
6 · The paper itself

Abstract

During aerobic growth,

Indexed as

AcetatesCitric Acid CycleStaphylococcus aureusAdenosine TriphosphateEnergy MetabolismGlucoseOxidation-ReductionSuccinate DehydrogenaseSuccinic AcidThermodynamicsAcetatesAdenosine TriphosphateGlucoseSuccinate DehydrogenaseSuccinic Acidacetate overflowmembrane crowdingoverflow metabolismredox imbalancethermodynamic bottleneck

Identifiers

PMID39745366
PMCPMC11774044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.