Evidence map›Paper›PMID 39744893›Full record

ArticleAging cell2025

Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice.

Xiaoxue Tian, Hao Kan, Liu Yang, Zhiwei Wang, Tiantian Zhang, Ka Zhang, Aiqin Mao, Xin Wen, Tingting Zhou, Xiaoyan Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. The CaInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoxue TianWuxi School of Medicine, Jiangnan University, Wuxi, China.
Hao KanWuxi School of Medicine, Jiangnan University, Wuxi, China.
Liu YangWuxi School of Medicine, Jiangnan University, Wuxi, China.
Zhiwei WangWuxi School of Medicine, Jiangnan University, Wuxi, China.
Tiantian ZhangWuxi School of Medicine, Jiangnan University, Wuxi, China.
Ka ZhangWuxi School of Medicine, Jiangnan University, Wuxi, China.
Aiqin MaoWuxi School of Medicine, Jiangnan University, Wuxi, China.
Xin WenWuxi School of Medicine, Jiangnan University, Wuxi, China.
Tingting ZhouWuxi School of Medicine, Jiangnan University, Wuxi, China.
Xiaoyan WangDepartment of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, China.
Xiaodong ZhangDepartment of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, China.
Lei FengWuxi School of Medicine, Jiangnan University, Wuxi, China.
Li GengWuxi School of Medicine, Jiangnan University, Wuxi, China.ORCID 0000-0002-4264-677X

Funding

Fundamental Research Funds for the Central Universities JUSRP123075National Natural Science Foundation of China 82100416National Natural Science Foundation of China 82200463Postdoctoral Fellowship Program of CPSF GZC20230981
6 · The paper itself

Abstract

Endothelial dysfunction, characterized by a decline in endothelial physiological functions, is a significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), a key member of Ca

Indexed as

AgingEndothelium, VascularReceptors, G-Protein-CoupledTRPV Cation ChannelsAnimalsHumansMaleMesenteric ArteriesMiceMice, Inbred C57BLMice, KnockoutVasodilationGPR35 protein, mouseReceptors, G-Protein-CoupledTrpv4 protein, mouseTRPV Cation Channelsagingcalciumendothelial cellendothelial dysfunctionGPR35protein–protein interactionTRPV4vasodilation

Identifiers

PMID39744893
PMCPMC12074021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.