Evidence map›Paper›PMID 39744580›Full record

ArticleJournal of Cancer2025

The causal association between neutrophil counts and the risk of lung cancer: a Mendelian randomization study.

Yunzhao Ren, Zhaojun Lu, Xiaoxue Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yunzhao RenSchool of Public Health, Zhejiang University School of Medicine, 866 Yuhangtang Rd., Hangzhou, Zhejiang 310058, China.
Zhaojun LuHangZhou Center for Disease Control and Prevention, 568 Mingshi Road, Hangzhou, Zhejiang 310021, China.
Xiaoxue LiuGlobal Health Research Division, Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increased neutrophil level in the blood is considered a risk factor for lung cancer (LC). However, establishment of causality is hampered by the inconsistent findings of observational studies. This study aimed to explore the causal association between neutrophil counts (NC) and LC risk in two populations via two-sample mendelian randomization (MR) analysis. The inverse-variance weighted method was used to evaluate causality. Sensitivity analyses were conducted to examine the stability of the results. Bidirectional MR analysis was performed to check reverse causality, and a multivariable MR analysis was conducted to adjust for confounding factors. The results revealed a significant causal relationship between NC and LC (OR=1.027, 95% CI: 1.005-1.050,

Indexed as

Causal associationLung cancerMendelian randomizationNeutrophil

Identifiers

PMID39744580
PMCPMC11660127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.