Evidence map›Paper›PMID 39744394›Full record

ArticleFrontiers in microbiology2024

The fungal gut microbiota in pediatric-onset multiple sclerosis.

Nelson Mok, Natalie C Knox, Feng Zhu, Douglas L Arnold, Amit Bar-Or, Charles Noah Bernstein, Christine Bonner, Jessica D Forbes, Morag Graham, Ruth Ann Marrie and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nelson MokDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Natalie C KnoxDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Feng ZhuDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Douglas L ArnoldDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Amit Bar-OrDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, United States.
Charles Noah BernsteinDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Christine BonnerScience Technologies Operations, Public Health Agency of Canada, Winnipeg, MB, Canada.
Jessica D ForbesEastern Ontario Regional Laboratory Association, Ottawa, ON, Canada.
Morag GrahamDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Ruth Ann MarrieDepartment of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
Julia O'MahonyDepartment of Pediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
E Ann YehDepartment of Pediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Yinshan ZhaoDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Gary Van DomselaarDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
Brenda BanwellChildren's Hospital of Philadelphia, Philadelphia, PA, United States.
Emmanuelle WaubantUCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Helen L TremlettDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on gut bacterial communities; none have examined the fungal microbiota (mycobiota) in persons with pediatric-onset multiple sclerosis (POMS). We examined the gut mycobiota in persons with and without POMS through a cross-sectional examination of the gut mycobiota from 46 participants' stool samples (three groups: 18 POMS, 13 acquired monophasic demyelinating syndromes [monoADS], and 15 unaffected controls). Using metataxonomic sequencing of the fungal internal transcribed spacer region 2, the fungal profiles were compared between participants using visualizations, statistical tests, and predictive analysis. While the mycobiome

Indexed as

case–controlfungal gut microbiomegut mycobiotamonophasic acquired demyelinating syndromemultiple sclerosispediatric

Identifiers

PMID39744394
PMCPMC11688249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.