ArticleFrontiers in public health2024
Association between urinary arsenic and hearing threshold shifts in adults in the United States, National Health and Nutrition Examination Survey, 2015-2016.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hearing loss (HL) is a common sensory disorder in humans. Studies on the relationship between arsenic, which is a highly toxic and widely distributed heavy metal with a health risk to humans, and hearing status in humans are contradictory and mostly focused on people living in arsenic-contaminated areas. This study investigated the association between urinary arsenic levels and hearing threshold shifts in the general population in the United States. Methods: Overall, 1,017 adults (aged 20-69 years) from the National Health and Nutrition Examination Survey (2015-2016) were included in this study. HL was defined as pure-tone average (PTA) ≥ 20 dB at frequencies 500, 1,000, 2000, and 4,000 Hz in the better-hearing ear. Total urinary arsenic (uAs) and dimethylarsinic acid (uDMA) levels were analyzed. Multivariate linear regression analyses and smooth curve fitting were performed to evaluate the correlations between uDMA, uAs, and low-, speech-, and high-frequency hearing levels. Results: The mean age of the participants was 42.13 ± 13.66 years, including weighted 48.67% men and 12.88% participants with sensorineural HL. After adjusting for potential confounders in the multivariate linear regression model, higher uDMA levels were significantly associated with poor low-, and speech-frequency PTAs, with no differences among participants by age or sex. Smooth curve fitting indicated a nonlinear relationship between uAs and high-frequency PTA hearing threshold shifts. The uAs levels were positively associated with high-frequency PTA until the turning point of 1.54 (adjusted Conclusion: We found positive associations between urinary arsenic metabolites uDMA, uAs levels and poor hearing threshold shifts in US adults. This study provides new evidence for the association between arsenic exposure and auditory function.
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