ArticleCureus2024
Pain Management in Fibromyalgia: Evaluating the Roles of Pregabalin, Duloxetine, and Milnacipran.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management of Juvenile Fibromyalgia: A Level I Evidence-Based Systematic Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Fibromyalgia is a chronic pain disorder characterized by widespread pain, fatigue, and sleep disturbances. The purpose of this study was to compare how well duloxetine, pregabalin, and milnacipran worked for fibromyalgia patients in terms of pain management, quality of life, and sleep quality. Methodology A prospective cohort research study with 193 fibromyalgia patients was carried out at the Abbas Institute of Medical Sciences, Muzaffarabad, Pakistan. For a total study duration of nine months, participants were prescribed milnacipran, pregabalin, or duloxetine for six months, and followed up monthly for an additional three months after completing therapy. At baseline and at the conclusion of the study, measures of pain intensity, quality of life (Fibromyalgia Impact Questionnaire, FIQ), and sleep quality (Pittsburgh Sleep Quality Index, PSQI) were taken. Analysis of variance (ANOVA) and paired t-tests were among the statistical studies carried out. Results Significant improvements in pain, quality of life, and sleep quality were shown by all three drugs. The most significant benefits were from duloxetine, which dramatically reduced pain and improved sleep and quality of life (p < 0.05). Pregabalin was less successful at improving quality of life than it was at reducing pain and promoting better sleep. Milnacipran had less of an effect on quality of life but showed modest effectiveness in managing fatigue and reducing discomfort. Due to moderate side effects, such as nausea and dizziness, duloxetine had greater rates of discontinuation. Conclusion Duloxetine was the most effective treatment, improving pain, quality of life, and sleep quality. Pregabalin is beneficial for pain and sleep management, while milnacipran remains a viable option for those with predominant fatigue. These results support the use of these medications in fibromyalgia treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.