Evidence map›Paper›PMID 39744254›Full record

ReviewCureus2024

Advancements in the Treatment of Multiple Myeloma.

Esteban Zavaleta-Monestel, Ricardo Quesada-Villaseñor, Monserrat Barrantes-López, Sebastián Arguedas-Chacón, Jeimy Campos-Hernández, Carolina Rojas-Chinchilla, Jonathan García-Montero, Josué Castro-Ulloa, Adriana Anchía-Alfaro, José Ricardo Montenegro-Chaves

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Esteban Zavaleta-MonestelPharmacy, Hospital Clinica Biblica, San Jose, CRI.
Ricardo Quesada-VillaseñorGeneral Medicine, Hospital Clinica Biblica, San José, CRI.
Monserrat Barrantes-LópezPharmacy, Universidad de Iberoamerica, San José, CRI.
Sebastián Arguedas-ChacónPharmacy, Hospital Clinica Biblica, San José, CRI.
Jeimy Campos-HernándezPharmacy, Universidad de Iberoamérica, San José, CRI.
Carolina Rojas-ChinchillaPharmacy, Hospital Clínica Bíblica, San José, CRI.
Jonathan García-MonteroPharmacy, Hospital Clínica Bíblica, San José, CRI.
Josué Castro-UlloaPharmacy, Hospital Clínica Bíblica, San José, CRI.
Adriana Anchía-AlfaroGeneral Medicine, Hospital Clínica Bíblica, San José, CRI.
José Ricardo Montenegro-ChavesHematology, Hospital Clínica Bíblica, San José, CRI.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) is the second most common hematological malignancy globally. Despite its reputation as an aggressive and fatal disease, recent advancements in treatment have significantly improved patient outcomes. Over the past decade, innovative therapies with fewer side effects have emerged, including proteasome inhibitors (e.g., bortezomib, carfilzomib, ixazomib), monoclonal antibodies (e.g., daratumumab, isatuximab, elotuzumab), immunomodulators (e.g., thalidomide, lenalidomide, pomalidomide), and corticosteroids (e.g., dexamethasone). Additionally, combination regimens utilizing these agents have demonstrated improved efficacy by targeting multiple pathways simultaneously. These therapies are more precise in their ability to attack myeloma cells, leading to enhanced patient quality of life, prolonged remission, and delayed disease progression. This article explores the evolution of MM therapies, highlighting the potential for a cure through ongoing breakthroughs in drug development and combination treatments. The analysis underscores the optimism surrounding the future of MM treatment and the need for continued research to make MM a manageable and potentially curable disease.

Indexed as

bispecific monoclonal antibodieschemotherapyimmunologic factorsmultiple myelomaneoplasmsproteasome inhibitorstherapeutics

Identifiers

PMID39744254
PMCPMC11691229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.