Evidence map›Paper›PMID 39744222›Full record

ArticleTheranostics2025

Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.

Xuekun Fu, Jie Huang, Xinxin Chen, Duoli Xie, Hongzhen Chen, Zhijian Liang, Zhuqian Wang, Yiying Liang, Aiping Lu, Chao Liang

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. RNA therapeutics: current status and future directions.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Dual Aptamers-Based SETDB1 PROTACs as Effective Anti-Tumor Strategies for Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuekun FuDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Jie HuangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Xinxin ChenDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Duoli XieDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Hongzhen ChenDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Zhijian LiangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Zhuqian WangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Yiying LiangShenzhen LingGene Biotech Co., Ltd., Shenzhen 518055, China.
Aiping LuInstitute of Integrated Bioinfomedicine and Translational Science (IBTS), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, China.
Chao LiangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aptamers, NucleotideBone NeoplasmsNucleolinOsteosarcomaProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-metAnimalsAntineoplastic AgentsApoptosisCell Line, TumorHumansMiceMice, Inbred BALB CMice, NudeMolecular Targeted TherapyOligodeoxyribonucleotidesAGRO 100Antineoplastic AgentsAptamers, NucleotideMDM2 protein, humanNucleolinOligodeoxyribonucleotidesPhosphoproteinsProto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-metRNA-Binding ProteinsAS1411c-METnucleolinosteosarcomaPROTAC

Identifiers

PMID39744222
PMCPMC11667235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.