Evidence map›Paper›PMID 39744155›Full record

ArticleFrontiers in cellular and infection microbiology2024

Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection.

Kinga P Böszörményi, Marieke A Stammes, Zahra Fagrouch, Fidel Acar, Henk Niphuis, Gwendoline Kiemenyi Kayere, Lisette Meijer, Eric J Snijder, Lia van der Hoek, Ben Berkhout and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kinga P BöszörményiDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Marieke A StammesDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Zahra FagrouchDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Fidel AcarDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Henk NiphuisDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Gwendoline Kiemenyi KayereDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Lisette MeijerDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Eric J SnijderMolecular Virology Laboratory, Leiden University Center of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Lia van der HoekLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Ben BerkhoutLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Willy M BogersDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Judith M A van den BrandDivision of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Ivanela KondovaDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Babs E VerstrepenDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.
Ernst J VerschoorDepartment of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection of an adult rhesus macaque with SARS-CoV-2 led to viral RNAemia in nose, throat, and lungs. The animal also presented extended fecal shedding of viral genomic and subgenomic messenger RNA and replication-competent virus for more than 3 weeks after infection. Positron emission tomography revealed increased intestinal glucose metabolism which was histologically related to inflammation of the ileum. These findings highlight the potential of the virus to cause gastrointestinal infections in macaques like this is also regularly observed in COVID-19 patients and substantiates the probability of virus transmission via the fecal-oral route. This study further adds the importance of nonhuman primates as a valuable animal model to study SARS-CoV-2 infection in humans.

Indexed as

COVID-19Disease Models, AnimalFecesMacaca mulattaRNA, ViralSARS-CoV-2Virus ReplicationVirus SheddingAnimalsInflammationLungRNA, ViralCOVID-19intestinal inflammationPET-CTrhesus macaqueSARS-CoV-2virus shedding

Identifiers

PMID39744155
PMCPMC11688216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.