Evidence map›Paper›PMID 39744142›Full record

ArticleFrontiers in ophthalmology2024

Unexpected retinal fluid compartment responses with anti-VEGF therapy in polypoidal choroidal vasculopathy: a case report of four patients.

Noa Gilead, Yu Jeat Chong, Farah N I Ibrahim, Christopher Sun, Kelvin Y C Teo, Chui Ming Gemmy Cheung

Abstract readCase Reports
In one paragraph

Article in Frontiers in ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Noa GileadSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Yu Jeat ChongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Farah N I IbrahimSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Christopher SunSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Kelvin Y C TeoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Chui Ming Gemmy CheungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case series describes responses to faricimab treatment in opposite directions in different fluid compartments in four patients with polypoidal choroidal vasculopathy (PCV). Despite reductions in retinal fluid (SRF) and stable visual acuity following treatment, all patients developed retinal pigment epithelium (RPE) elevation. Over a 12-15 months follow-up, three patients exhibited a gradual decrease in RPE elevation, with one case resolving completely. These findings suggest that fluid compartments in PCV may respond differently to treatment and add to the understanding of PCV by highlighting the complex interplay between different retinal fluid compartments in response to treatment.

Indexed as

case reportpigment epithelial detachment (PED)polypoidal choroidal vasculopathy (PCV)retinal fluid compartmentssubretinal fluid (SRF)unexpected response

Identifiers

PMID39744142
PMCPMC11688388

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.