ArticleFrontiers in neurology2024
Evaluating iron deposition in gray matter nuclei of patients with acute ischemic stroke using quantitative susceptibility mapping.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Prediction of early neurological deterioration using quantitative susceptibility mapping in small artery occlusion ischemic stroke.IBRO neuroscience reports · 2026Article
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8 authors.
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Abstract
Objectives: Understanding the microscopic pathophysiological mechanisms underlying acute ischemic stroke (AIS) is vital for facilitating early clinical diagnosis and intervention. In this study, we aimed to quantitatively assess brain iron changes in gray matter (GM) nuclei in patients with AIS via quantitative susceptibility mapping (QSM). Methods: Thirty-four patients with AIS and thirty age-and sex-matched healthy controls (HCs) were included. QSM and conventional magnetic resonance imaging were performed. Intergroup differences in regional susceptibility values were calculated for the bilateral caudate nucleus (CN), globus pallidus (GP), putamen (PUT), red nucleus (RN), substantia nigra (SN), thalamus (THA), and dentate nucleus (DN). A receiver operating characteristic curve was plotted to evaluate the classification and diagnostic performance of susceptibility values in distinguishing patients with AIS from HCs. Multiple linear regression analysis was used to investigate the impact of clinical variables on susceptibility values. Correlation analysis was used to assess the correlation between regional iron variations and clinical scores. A paired t test was used to calculate the differences in susceptibility values between the bilateral hemispheres in the participants. Results: Compared with the HCs, the patients with AIS had significantly increased susceptibility values in the bilateral CN and PUT ( Conclusion: This study revealed increased iron concentrations in the GM nuclei of patients with AIS. Iron deposition in GM nuclei may be a potential biomarker for further understanding the pathophysiological mechanism underlying AIS.
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