Evidence map›Paper›PMID 39744109›Full record

ArticleFrontiers in neurology2024

Establishment and evaluation of a carotid artery dissection model in rats.

Shufan Zhang, Zhenxiang Han, Ying Cao, Weicheng Wu, Yuanzeng Liu, Shilin Yang, Xiaochao Feng, Chun Yu, Zhu Zhu, Qiang Dong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shufan Zhang *Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Zhenxiang Han *Department of Neurology and Neurological Rehabilitation, Shanghai Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ying Cao *Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Weicheng WuSchool of Life Sciences, Fudan University, Shanghai, China.
Yuanzeng LiuGumei Community Health Service Center of Shanghai Minhang District, Shanghai, China.
Shilin YangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaochao FengDepartment of Neurology, Shanghai Longhua Hospital, Shanghai, China.
Chun YuDepartment of Intensive Care Unit of West Campus, Huashan Hospital, Fudan University, Shanghai, China.
Zhu ZhuDepartment of Neurology, Indianan University Health, Indianapolis, IN, United States.
Qiang DongDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xiang HanDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Given the lack of models for carotid artery dissections (CAD), we aim to investigate effects of beta-aminopropionitrile (BAPN) combined with physical damage on the arterial walls of rats, and to establish a high-incidence and low-mortality CAD model. Methods: Sixteen SPF SD rats (3-week-old) were divided into two groups. Group B was given 0.25% BAPN solution and group W was given water. Then we established an animal model of CAD by carotid artery torsion. One of the two carotid arteries in each rat was randomly selected for torsion. We got four groups of blood vessels following above-mentioned methods: BAPN plus torsion group (group Bt), BAPN plus non-torsion group (group Bn), water plus torsion group (group Wt), and water plus non-torsion group (group Wn). The hematoxylin and eosin (HE) staining and Verhoeff's Van Gieson (EVG) staining were performed to observe structures of arteries. Immunofluorescence staining was used to detect structural proteins in vessels. We used triphenyltetrazolium chloride (TTC) staining and neurological function assessment to detect the infarct area of brain and neurological deficits in rats with carotid dissection to verify the validity of the rat model. Results: BAPN treatment significantly affected the weight gain of rats, but had little effect on survival during the first 5 weeks. The group Bt had the highest incidence of CAD among all groups ( Conclusion: The animal model of CAD can be feasible to establish by mechanical torsion combined with BAPN free drinking. With this method, the animal mortality was low and the model formation rate was high. This model will enable further studies on CAD.

Indexed as

animal modelbeta-aminopropionitrile (BAPN)carotid artery dissectionmechanical torsionrat

Identifiers

PMID39744109
PMCPMC11688284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.