Evidence map›Paper›PMID 39744053›Full record

ArticleAsia Oceania journal of nuclear medicine & biology2025

Use of the specific binding ratio distribution to characterise multiple system atrophy in advanced iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane serotonin transporter imaging.

Kazuya Takahashi, Masanobu Ishiguro, Yoshitaka Inui, Takashi Ichihara, Cong Shang, Ryunosuke Nagao, Yasuaki Mizutani, Mizuki Ito, Hirohisa Watanabe, Nobutoku Motomura and 1 more

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In one paragraph

Article in Asia Oceania journal of nuclear medicine & biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Serotonin Transporter Distribution in the Brainstem of Multiple-System Atrophy-Parkinsonian Type: Insights from Pathology andJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazuya TakahashiDepartment of Radiology, Fujita Health University School of Medicine, Aichi, Japan.
Masanobu IshiguroSection of Radiology, Fujita Health University Hospital, Aichi, Japan.
Yoshitaka InuiDepartment of Radiology, Fujita Health University School of Medicine, Aichi, Japan.
Takashi IchiharaDepartment of Radiology, Fujita Health University School of Medicine, Aichi, Japan.
Cong ShangDepartment of Radiology, Fujita Health University School of Medicine, Aichi, Japan.
Ryunosuke NagaoDepartment of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
Yasuaki MizutaniDepartment of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
Mizuki ItoDepartment of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
Hirohisa WatanabeDepartment of Neurology, Fujita Health University School of Medicine, Aichi, Japan.
Nobutoku MotomuraCanon Medical Systems, Otawara, Tochigi, Japan.
Hiroshi ToyamaDepartment of Radiology, Fujita Health University School of Medicine, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Sudden death in multiple system atrophy (MSA) is caused by decreased serotonergic innervation, but there is no routine test method for this decrease. In addition to dopamine transporters, iodine-123-labelled N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ( Methods: Single-photon emission computed tomography (SPECT) and T1-weighted magnetic resonance (MR) images were aligned. The MR (T1) images were used to set a reference site for the occipital-lobe SBR in each subject, and measurements were made from the SPECT image at the same position. The pixel values and accumulation ratios compared with the occipital lobe were calculated, and a regional SBR distribution image was created. We identified areas with SERT accumulation above a certain level. Results: The SERT accumulation site was visualised as an SBR value on MR images. The accumulation distribution (SERT distribution) on the SBR images significantly differed between the healthy subjects and patients with MSA. Conclusion: SERT accumulation was noted in the brain-stem region, indicating that SBR imaging was useful for viewing and quantifying SERT accumulation.

Indexed as

Binding potentialMultiple system atrophySerotonin transporterSPECT

Identifiers

PMID39744053
PMCPMC11682478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.