Evidence map›Paper›PMID 39743683›Full record

ArticleBritish journal of haematology2025

Plasma inflammatory and angiogenic protein profiling of patients with sickle cell disease.

L A de Ligt, A E Gaartman, K Konté, S Thakoerdin, K Fijnvandraat, T W Kuijpers, R van Bruggen, B J Biemond, E Nur

Abstract read
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L A de LigtDepartment of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.ORCID https://orcid.org/0009-0003-2934-4739
A E GaartmanDepartment of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
K KontéDepartment of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-6637-0352
S ThakoerdinDepartment of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
K FijnvandraatDepartment of Pediatric Hematology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-0904-4360
T W KuijpersDepartment of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
R van BruggenDepartment of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.
B J BiemondDepartment of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4426-5743
E NurDepartment of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-7069-930X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we aimed to explore the inflammatory and angiogenic pathways in sickle cell disease (SCD). We used proximity extension assay technology (Olink) to measure 92 plasma proteins involved in inflammation and angiogenesis. Plasma samples were collected from 57 SCD patients (sickle cell anaemia/HbS-β

Indexed as

Anemia, Sickle CellAngiogenic ProteinsBlood ProteinsAdolescentAdultBiomarkersCase-Control StudiesFemaleHematopoietic Stem Cell TransplantationHumansHydroxyureaInflammationMaleMiddle AgedNeovascularization, PathologicYoung AdultAngiogenic ProteinsBiomarkersBlood ProteinsHydroxyureaangiogenesisinflammationproteomicssickle cell disease

Identifiers

PMID39743683
PMCPMC11886948

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.