Evidence map›Paper›PMID 39743595›Full record

ArticleNature2025

Gliomagenesis mimics an injury response orchestrated by neural crest-like cells.

Akram A Hamed, Kui Hua, Quang M Trinh, Benjamin D Simons, John C Marioni, Lincoln D Stein, Peter B Dirks

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
  7. Article
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  9. Review
  10. Microglial fructose metabolism is essential for glioblastoma growth.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. How cancer arises: Genetics releases, plasticity creates, genetics stabilizes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akram A HamedDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9239-2942
Kui Hua *Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2228-7025
Quang M Trinh *Ontario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID 0000-0002-3602-2290
Benjamin D SimonsEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK. bds10@cam.ac.uk.ORCID 0000-0002-3875-7071
John C MarioniCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. marioni@ebi.ac.uk.ORCID 0000-0001-9092-0852
Lincoln D SteinDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. lincoln.stein@oicr.on.ca.
Peter B DirksDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. peter.dirks@sickkids.ca.ORCID 0000-0001-5718-6465

Funding

Medical Research Council MC_PC_17230
6 · The paper itself

Abstract

Glioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these tumours exhibit a degree of genetic and cellular heterogeneity that provides few clues to the mechanisms that initiate and drive gliomagenesis

Indexed as

Brain NeoplasmsCarcinogenesisGlioblastomaNeural CrestAnimalsBrainCell LineageClone CellsDisease Models, AnimalDNA Copy Number VariationsFemaleGene DeletionHumansMagnetic Resonance ImagingMaleMice

Identifiers

PMID39743595
PMCPMC11821533

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.