ArticleNature2025
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Vascular-lymphatic dual circulation in bone health and disease: Mechanistic coupling and translational therapeutics.Journal of orthopaedic translation · 2026Review
- T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.Bone research · 2026Review
- Transcription factor 19 modulates fatty acid elongation and unfolded protein response to attenuate palmitic acid-induced hepatic dysfunction.Nature communications · 2026Article
- Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration.Gels (Basel, Switzerland) · 2026Article
- The bone marrow microenvironment during homeostasis and after myeloablation.Journal of bone and mineral metabolism · 2026Review
- Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- From metabolic antagonism to homeostatic restoration: rewiring hepatic stellate cell bioenergetics for liver fibrosis reversal.Frontiers in medicine · 2026Review
- Sympathetic regulation of bone homeostasis and remodeling: molecular mechanisms, pathophysiological roles, and therapeutic implications.Frontiers in immunology · 2026Review
- Reconstruction of hematopoietic stem cell nichesMaterials today. Bio · 2025Review
- NO-immune privilege for hematopoietic stem cells.Cell research · 2025Article
- Role and prognostic value of oncostatin M and its receptor OSMR in acute myeloid leukemia, myeloproliferative neoplasms and non-hematological malignancies.Frontiers in oncology · 2025Article
- Transfer of bone marrow niche-residential regulatory T cells ameliorates experimental colitis.Cellular immunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Kazuhiro Furuhashi *Columbia Center for Translational Immunology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0003-2476-688X
Miwako Kakiuchi *Columbia Center for Translational Immunology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-6300-6771
Ryosuke Ueda *Columbia Center for Translational Immunology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Hiroko OdaCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8268-1529
Simone UmmarinoHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA.
Alexander K EbralidzeHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA.
Mahmoud A BassalHarvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4322-2968
Chen MengCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Tatsuyuki SatoCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Jing LyuCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Min-Guk HanCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3797-3354
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-8858-632X
Yu WatanabeDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuriko SawaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Daisuke KatoDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroaki WakeDepartment of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-8543-4590
Boris ReizisTranslational Immunology Center, Department of Pathology, New York University, New York, NY, USA.ORCID 0000-0003-1140-7853
John A FrangosLa Jolla Bioengineering Institute, La Jolla, CA, USA.
David M OwensDepartment of Dermatology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0003-0297-4370
Daniel G TenenHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA.
Ionita C GhiranCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Simon C RobsonCenter for Inflammation Research, Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6374-0194
Joji FujisakiColumbia Center for Translational Immunology, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. jfujisak@bidmc.harvard.edu.ORCID 0000-0002-2631-9488
Funding
Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DANIEL G TENEN · 2017 to 2026
$24.6MPROGRAM IN BLOOD COAGULATION AND VASCULAR BIOLOGYT32HL007917 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Robert C Flaumenhaft · 1999 to 2026
$11.1MPrivileged and primitive hematopoietic stem cells, niches, and regulatory T cellsR01HL129506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FUJISAKI, JOJI · 2016 to 2025
$5.1MIntravital analysis of hematopoietic stem cells in their bone marrow niche - Resubmission - 1R01HL152637 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FOOKSMAN, DAVID R, REIZIS, BORIS · 2021 to 2024
$2.6MInvestigating the role for Utrophin in age-related decline of the Merkel lineageR01AG073874 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWENS, DAVID MICHAEL · 2021 to 2025
$2.0MRoles and therapeutic potential of CD150high niche-associated regulatory T cells in bone marrow injury and engraftmentR01HL145154 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FUJISAKI, JOJI · 2019 to 2022
$1.9MIdentification of unique nitric oxide-expressing hematopoietic stem cells and their special vascular nicheR01DK121889 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FUJISAKI, JOJI · 2020 to 2023
$1.7MNHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL129506NHLBI NIH HHS R01 HL145154NHLBI NIH HHS R01 HL152637NHLBI NIH HHS T32 HL007917NIA NIH HHS R01 AG073874NIDDK NIH HHS R01 DK121889
Abstract
Stem cells reside in specialized microenvironments, termed niches, at several different locations in tissues
Indexed as
Bone MarrowHematopoietic Stem CellsImmune ToleranceStem Cell NicheAnimalsAntigens, CDAutophagyCapillariesFemaleImmune PrivilegeMaleMiceMice, Inbred C57BLNitric OxideNitric Oxide Synthase Type IIIRegenerationAntigens, CDNitric OxideNitric Oxide Synthase Type III
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.