ArticleNature2025
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80citing papers in PubMed
–field-weighted citation impact
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Who cites it
80 citing papers in PubMed.
- Review
- Integrated analysis of single-cell transcriptome identifies a glial-neurovascular signaling trajectory in brain repair after ischemia.Biology direct · 2026Article
- Age and sex-dependent alteration in AMPA receptor density in living human brain.European journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Integrative transcriptomics identifies shared aging-associated inhibitory-neuron states and prioritizes RGL2 across postoperative delirium and Alzheimer's disease.Journal of molecular neuroscience : MN · 2026Article
- Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis.Neuron · 2026Article
- SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program.The EMBO journal · 2026Article
- Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.Science (New York, N.Y.) · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Mapping of oxytocin- and arginine vasopressin-expressing neurons with calbindin 1 or reelin in the male mouse brain.Journal of neuroendocrinology · 2026Article
- Innate immune signaling and functions in astrocytes.Nature immunology · 2026Review
- Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.EMBO reports · 2026Article
- Friend or foe? Glial-vascular interactions in health and neurodegenerative disease.Pharmacological reviews · 2026Review
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research.Cell reports · 2026Article
- Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy.Translational neurodegeneration · 2026Review
- Neuronal subtype-specific ribosomal protein mRNA expression.RNA (New York, N.Y.) · 2026Article
- ProtoCloud: A prototypical self-explaining model for single-cell analysis.Cell genomics · 2026Article
- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
- Beyond satiety: unraveling the complex roles of POMC neurons in behavior and metabolism.Reviews in endocrine & metabolic disorders · 2026Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Kelly JinAllen Institute for Brain Science, Seattle, WA, USA.
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9361-5607
Cindy T J van VelthovenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5120-4546
Eitan S KaplanAllen Institute for Brain Science, Seattle, WA, USA.
Katie GlattfelderAllen Institute for Brain Science, Seattle, WA, USA.
Samuel T BarlowAllen Institute for Brain Science, Seattle, WA, USA.
Gabriella BoyerAllen Institute for Brain Science, Seattle, WA, USA.
Daniel CareyAllen Institute for Brain Science, Seattle, WA, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.
Anish Bhaswanth ChakkaAllen Institute for Brain Science, Seattle, WA, USA.
Rushil ChakrabartyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1722-8557
Michael ClarkAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8006-4332
Max DeparteeAllen Institute for Brain Science, Seattle, WA, USA.
Marie DesiertoAllen Institute for Brain Science, Seattle, WA, USA.
Amanda GaryAllen Institute for Brain Science, Seattle, WA, USA.
Jessica GloeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8343-3423
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.
Nathan GuilfordAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6188-7333
Junitta GuzmanAllen Institute for Brain Science, Seattle, WA, USA.
Daniel HirschsteinAllen Institute for Brain Science, Seattle, WA, USA.
Changkyu LeeAllen Institute for Brain Science, Seattle, WA, USA.
Elizabeth LiangAllen Institute for Brain Science, Seattle, WA, USA.
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4738-5062
Melissa RedingAllen Institute for Brain Science, Seattle, WA, USA.
Kara RonellenfitchAllen Institute for Brain Science, Seattle, WA, USA.
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8361-5152
Josh SevignyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9297-4800
Nadiya ShapovalovaAllen Institute for Brain Science, Seattle, WA, USA.
Lyudmila ShulgaAllen Institute for Brain Science, Seattle, WA, USA.
Josef SulcAllen Institute for Brain Science, Seattle, WA, USA.
Amy TorkelsonAllen Institute for Brain Science, Seattle, WA, USA.
Herman TungAllen Institute for Brain Science, Seattle, WA, USA.
Boaz LeviAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8346-872X
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3565-9126
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3142-1970
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA. bosiljkat@alleninstitute.org.ORCID 0000-0002-6861-4506
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA. hongkuiz@alleninstitute.org.ORCID 0000-0002-0326-5878
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7MMolecular and anatomical characterization of cell types in the aging mouse brainR01AG066027 · NIA · ALLEN INSTITUTE · PI TASIC, BOSILJKA, ZENG, HONGKUI · 2019 to 2023
$5.9MNIA NIH HHS R01 AG066027NIMH NIH HHS U19 MH114830
Abstract
Biological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function
Indexed as
AgingBrainGene Expression ProfilingTranscriptomeAnimalsAstrocytesCluster AnalysisFemaleMaleMiceMice, Inbred C57BLNeurogliaNeuronsOrgan SpecificitySingle-Cell Analysis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.