Evidence map›Paper›PMID 39743588›Full record

ArticleNature2025

Structural diversity of axonemes across mammalian motile cilia.

Miguel Ricardo Leung, Chen Sun, Jianwei Zeng, Jacob R Anderson, Qingwei Niu, Wei Huang, Willem E M Noteborn, Alan Brown, Tzviya Zeev-Ben-Mordehai, Rui Zhang

Abstract readComparative Study
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Functional Diversity and Emerging Roles of Human NME/NDPK Group II Proteins.International journal of molecular sciences · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Exome sequencing-based identification ofFrontiers in molecular biosciences · 2026
    Article
  18. Article
  19. Atomic models of the Toxoplasma cell invasion machinery.Nature structural & molecular biology · 2026
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miguel Ricardo Leung *Structural Biochemistry Group, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, the Netherlands.
Chen Sun *Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7469-2052
Jianwei Zeng *Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6880-3366
Jacob R Anderson *Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Qingwei NiuDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Wei HuangDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-2097-8148
Willem E M NotebornNetherlands Centre for Electron Nanoscopy (NeCEN), Leiden University, Leiden, the Netherlands.ORCID 0000-0003-1211-6222
Alan BrownDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. alan_brown@hms.harvard.edu.ORCID 0000-0002-0021-0476
Tzviya Zeev-Ben-MordehaiStructural Biochemistry Group, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, the Netherlands. z.zeev@uu.nl.ORCID 0000-0002-2571-550X
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA. zhangrui@wustl.edu.ORCID 0000-0003-3159-9565

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Mechanoregulation of Ciliary MotilityR01GM141109 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2021 to 2025
$2.1M
Structural and functional studies of axonemal microtubule inner proteins (MIPs)R01GM138854 · NIGMS · WASHINGTON UNIVERSITY · PI ZHANG, RUI · 2020 to 2024
$2.0M
Structural characterization of single, double and triple-headed axonemal dyneinsR01GM143183 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2022 to 2025
$1.4M
NIGMS NIH HHS R01 GM138854NIGMS NIH HHS R01 GM141109NIGMS NIH HHS R01 GM143183NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii

Indexed as

AxonemeCiliaAdenosine TriphosphateAnimalsAxonemal DyneinsCryoelectron MicroscopyFemaleMaleMammalsMiceMicrotubulesModels, MolecularMolecular ChaperonesOviductsProteomicsSpermatozoaAdenosine TriphosphateAxonemal DyneinsMolecular Chaperones

Identifiers

PMID39743588
PMCPMC11779644

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.