ReviewNature reviews. Neuroscience2025
The brain's action-mode network.
Review in Nature reviews. Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Predicting treatment response to transcutaneous auricular vagus nerve stimulation in patients with insomnia: resting-state functional connectivity based multivoxel pattern analysis.BMC psychiatry · 2026Trial
- Cortical microarchitecture supports preadolescent functional brain network connectivity.bioRxiv : the preprint server for biology · 2026Article
- Dynamic fMRI networks of human emotion.eLife · 2026Article
- A cortical gradient in area 55b links language and somato-cognitive action networks.Research square · 2026Article
- Conative inference as a mechanism of allostatic resilience: wanting to be and being to want.Cognitive, affective & behavioral neuroscience · 2026Review
- Causal Mapping of Bodily Awareness and Mesoscale Circuit Organization in the Human Cingulate and Precuneus.Research square · 2026Article
- Cognitive ability in childhood predicts adolescent structural and functional brain development: A longitudinal study.Developmental cognitive neuroscience · 2026Article
- Separate dorsolateral prefrontal cortex regions participate in distinct large-scale networks differentially recruited for social and cognitive control functions.Journal of neurophysiology · 2026Article
- Linking temporal dynamics of children's natural behavior to brain development.Developmental cognitive neuroscience · 2026Article
- Hypoxia and TTR dysregulation in astrocytes from Parkinson's disease with a specific mitochondrial haplogroup: A single-cell analysis.Neural regeneration research · 2026Article
- Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.Science advances · 2026Article
- Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.Nature neuroscience · 2026Article
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- Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Precision Functional Parcellation of the Human Cortex via Rest-Task fMRI Fusion.bioRxiv : the preprint server for biology · 2026Article
- Cognitive control networks causally support implicit emotion regulation: evidence from dlPFC stimulation and directed functional connectivity.Scientific reports · 2026Article
- The interplay between executive function and learning disabilities: Developmental cognitive neuroscience perspectives on reading, math, and ADHD.Developmental cognitive neuroscience · 2026Review
- Beyond the Homunculus-SCAN-AMN as a Shared Action-Oriented Neural Substrate across Movement Disorders.Movement disorders : official journal of the Movement Disorder Society · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is always intrinsically active, using energy at high rates while cycling through global functional modes. Awake brain modes are tied to corresponding behavioural states. During goal-directed behaviour, the brain enters an action-mode of function. In the action-mode, arousal is heightened, attention is focused externally and action plans are created, converted to goal-directed movements and continuously updated on the basis of relevant feedback, such as pain. Here, we synthesize classical and recent human and animal evidence that the action-mode of the brain is created and maintained by an action-mode network (AMN), which we had previously identified and named the cingulo-opercular network on the basis of its anatomy. We discuss how rather than continuing to name this network anatomically, annotating it functionally as controlling the action-mode of the brain increases its distinctiveness from spatially adjacent networks and accounts for the large variety of the associated functions of an AMN, such as increasing arousal, processing of instructional cues, task general initiation transients, sustained goal maintenance, action planning, sympathetic drive for controlling physiology and internal organs (connectivity to adrenal medulla), and action-relevant bottom-up signals such as physical pain, errors and viscerosensation. In the functional mode continuum of the awake brain, the AMN-generated action-mode sits opposite the default-mode for self-referential, emotional and memory processing, with the default-mode network and AMN counterbalancing each other as yin and yang.
Indexed as
Identifiers
39743556What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.